Isolated Liver Perfusion With Oxaliplatin

Inclusion Criteria:

- Patients will be included that are scheduled to undergo surgery for placement of
hepatic arterial infusion pump for HAI therapy and

- Histologically or cytologically proven measurable metastatic colorectal cancer limited
to the parenchyma of the liver with no evidence of unresectable extrahepatic disease
by preoperative radiological studies. Limited resectable extrahepatic disease is
acceptable.

- No chemotherapy, radiotherapy, or biologic therapy for their malignancy in the 4 weeks
prior to the liver perfusion and must have recovered from all side effects.

- An ECOG performance standard of 0, 1 or 2 for 24 hours prior to surgery.

- Adequate hepatic function as evidenced by bilirubin < 2.0 mg/dL and a PT < 2 seconds
greater than the upper limit of normal.

- Age equal to 18 years or older and greater than 30 kg.

- Platelet counts greater than 100,000, a hematocrit > 27.0, a white blood count >
3000/microliter, and a creatinine less than or equal to 1.5 mg/dL or a creatinine
clearance of > 60 mL/min. Patients with elevations in hepatic transaminases secondary
to the presence of metastatic disease in the liver are eligible.

- Aware of the neoplastic nature of his/her illness, the experimental nature of the
therapy, alternative treatments, potential benefits, and risks and willing to sign an
informed consent.

- The disease in the liver must be considered unresectable as defined by greater than
three sites of disease in the liver, bilobar disease, and tumor abutting major
vascular or ductal structures making anatomic resection with preservation of liver
function impossible.

Exclusion Criteria:

- Pregnant patients and nursing mothers will be excluded due to the unknown effects of
oxaliplatin on the fetus or newborn

- Patients taking immunosuppressive drugs or on chronic anticoagulation will not be
eligible.

- Patients with active infections are not eligible.

- Patients with biopsy proven cirrhosis or evidence of significant portal hypertension
manifested by ascites, esophageal varices on endoscopy, or radiologic studies showing
significant collateral vessels around the organs drained by the portal venous system
will be excluded.

- Patients with ischemic cardiac disease or history of congestive heart failure with an
LVEF < 40% will be excluded.

- Patients with COPD or other chronic pulmonary disease with PFT's indicating an FEV<
50% predicted for age will be excluded.

- Patients with a history of veno-occlusive disease of the liver are ineligible.