Genetic Variability and Biomarkers in Children With Acute Lung Injury
| Status: | Withdrawn |
|---|---|
| Conditions: | Hospital, Pulmonary, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | Any - 18 |
| Updated: | 4/21/2016 |
| Start Date: | October 2009 |
| End Date: | June 2013 |
Acute Lung Injury (ALI) and the more severe Acute Respiratory Distress Syndrome (ARDS) are a
significant problem in Pediatric Intensive Care Units, affecting up to 16 of every 1000
children admitted to these units. These disorders carry with them high mortality rates as
well as numerous long-term effects for the surviving children. As the effects of these
diseases have significant social and economic ramifications for affected children and their
families, research on the development of ALI/ARDS could significantly change how physicians
understand the disease and treat patients.
There are a wide range of problems which make certain PICU patients more likely to develop
either ALI or ARDS. This research aims to determine which of these children are at the
greatest risk for ALI/ARDS by examining differences in plasma biomarkers and in DNA of a
large number of PICU patients. We are hypothesizing that significant differences in the
level of specific plasma biomarkers or in the frequency of specific DNA variants exist in
children who develop ALI/ARDS.
significant problem in Pediatric Intensive Care Units, affecting up to 16 of every 1000
children admitted to these units. These disorders carry with them high mortality rates as
well as numerous long-term effects for the surviving children. As the effects of these
diseases have significant social and economic ramifications for affected children and their
families, research on the development of ALI/ARDS could significantly change how physicians
understand the disease and treat patients.
There are a wide range of problems which make certain PICU patients more likely to develop
either ALI or ARDS. This research aims to determine which of these children are at the
greatest risk for ALI/ARDS by examining differences in plasma biomarkers and in DNA of a
large number of PICU patients. We are hypothesizing that significant differences in the
level of specific plasma biomarkers or in the frequency of specific DNA variants exist in
children who develop ALI/ARDS.
Inclusion Criteria:
- Consecutive intubated pediatric patients (≥ 2 weeks of age and ≥ 42 weeks corrected
gestational age and ≤ 18 years of age) supported on mechanical ventilation for acute
pulmonary parenchymal disease enrolled in the RESTORE study.
Exclusion Criteria:
- Intubated and mechanically ventilated for immediate post-operative care and
stabilization
- Cyanotic heart disease with unrepaired or palliated right to left intracardiac shunt
- History of single ventricle at any stage of repair
- Congenital diaphragmatic hernia or paralysis
- Primary pulmonary hypertension
- Critical airway (e.g., post laryngotracheal construction) or anatomical obstruction
of the lower airway (e.g., mediastinal mass)
- Ventilator dependent (including noninvasive) on PICU admission (chronic assisted
ventilation)
- Neuromuscular respiratory failure
- Spinal cord injury above the lumbar region
- Pain managed by patient controlled analgesia (PCA) or epidural catheter
- Family/medical team has decided not to provide full support (patient treatment
considered futile)
- Enrolled in any other sedation clinical trial concurrently or within the last 30 days
- Known allergy to any of the study medications
We found this trial at
1
site
9000 W Wisconsin Ave #270
Milwaukee, Wisconsin 53226
Milwaukee, Wisconsin 53226
(414) 266-2000
Children's Hospital of Wisconsin Nothing matters more than our children. At Children's Hospital of Wisconsin,...
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