Effect of Dietary Fat When Eaten With Fructose Versus Glucose

After 2 screening visits including an exercise test, DEXA and CT scan, qualifiers begin a 7
day diet with 20% fat, 65% carbohydrate (with 20% glucose) and 15 % protein. Participants
consume 2 meals per day at PBRC with lunch and weekend meals packed to go. Following a test
day, participants are randomized to one of 3 diet assignments and then test again:

1)20% fat, 65% carbohydrate (with 20% glucose beverage), 15% protein 2)40% fat, 45%
carbohydrate (with 20% glucose beverage), 15% protein 3)40% fat, 45% carbohydrate (with 20%
fructose beverage), 15% protein On Day 7 and again 14 days later participants have labs, an
oral Glucose tolerance test, hepatic and intramuscular lipid measures by MRS, vital signs
and waist measurement.

Inclusion Criteria:

- BMI between 25 and 35 kg/m2 inclusive

- At least one of the following:

1. Impaired fasting glucose between 100-125 mg/dl inclusive

2. HDL below 40 mg/dl for men or below 50 mg/dl for females

3. Triglycerides between 150 mg/dl and 400 mg/dl inclusive

4. Blood pressure above or equal to 135 / 85 mm Hg

- Waist circumference >94cm (37 inches) for men or >80cm for women

- Mainly Healthy

Exclusion Criteria:

- Unable or unlikely to eat study foods and only foods provided by PRBC

- Taking routine medications except birth control pills

- Smoke, Abuse drugs,or Alcohol

- Pregnant or breastfeeding, irregular menstrual cycles, Post-menopausal,or PCOS

- Diabetes, heart, lung, liver, blood, or Kidney disease