Prospective Measurement of Post-Treatment Lymphedema

If you choose to take part in this study, you will have measurements taken of your arms or
legs using a Perometer and a bioimpedance machine. The Perometer is a machine that
painlessly measures the fluid in your limb using two-directional infrared lights. These
lights are located in the frame of the machine that encircles the arm or leg during the
measurement. The bioimpedance is a machine that measures the fluid in your arm or leg by
passing a very small current through the body similar to an electrocardiogram (EKG). These
very small currents are located in electrodes that are placed on the hands and feet during
the measurement. Both machines are able to pick up changes in limb size.

You will also be asked to complete a set of questionnaires relating to any symptoms that you
may experience in your limbs and/or trunk (chest, stomach, and hip areas) during and
following your standard cancer treatment.

Additional questionnaires, along with your limb measurements, will be done at your
regularly-scheduled follow-up clinic visits, 3-6 months, 9-12 months, 15-18 months, 21-24
months and 27- 30 months. You will complete the additional questionnaires using a laptop
computer or a hardcopy. The measurements and questionnaires will take 45-60 minutes to
complete each time.

Some of the data from this study may be sent to the University of Missouri for analysis. The
data that is sent will not have any personal identifiers. Researchers at University of
Missouri will not be able to link the data to the protected health information or personal
identity of any individual participant.

This is an investigational study. Up to 350 patients will take part in this study. All
patients will be enrolled at MD Anderson.

Inclusion Criteria:

1. Patients with a confirmed diagnosis (M.D. Anderson pathology) of invasive cutaneous
melanoma (stages I-III) will be recruited for participation as they present for their
initial clinical evaluation to the University of Texas M.D. Anderson Melanoma and
Skin Center.

2. Prior to surgical treatment

3. Patients who can knowledgeably and voluntarily provide an informed consent to
participate. The informed consent will be signed and dated.

4. Fluent in English.

5. At least 18 years of age.

Exclusion Criteria:

1. Patients with a prior history of lymphedema or melanoma prior to treatment.

2. Patients who are unable to consent due to other medical illnesses or disorientation
to person, place or time.

3. Patients with known distant metastatic disease (Stage IV).

4. Patients with implanted device (pace maker), orthopedic implants, and metal frames.

5. Presence of concurrent malignancy that requires active treatment, such as
chemotherapy or biotherapy, prior to enrollment.