ACT-293987 in Pulmonary Arterial Hypertension



Status:Active, not recruiting
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:1/25/2019
Start Date:December 1, 2009
End Date:February 1, 2021

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Trial Summary
Trial Overview
Inclusion Criteria

Long-term Single-arm Open-label Study, to Assess the Safety and Tolerability of Selexipag (ACT-293987) in Patients With Pulmonary Arterial Hypertension

Long-term, single-arm, multicenter, open-label extension, Phase 3 study, to evaluate the
safety and tolerability of ACT-293987 in patients with PAH who participated in the
double-blind study AC-065A302 (GRIPHON)


Inclusion Criteria:

- Patients who participated to the double-blind study AC-065A302 and either had a
morbidity event or had completed the study as scheduled per protocol.

- Signed informed consent.

Exclusion Criteria:

- Patients who have started receiving prostacyclin (epoprostenol) or prostacyclin
analogs (i.e., treprostinil, iloprost, beraprost) since the last study drug intake in
AC-065A302/GRIPHON.

- Severe hepatic impairment (Child-Pugh C).

- Females who are pregnant or who plan to become pregnant during the study, or are
breastfeeding.

- Any known factor or disease that might interfere with treatment compliance, study
conduct or interpretation of the results, such as drug or alcohol dependence, or
psychiatric disease.
We found this trial at
36
sites
University of California San Diego Medical Center (La Jolla)
La Jolla, California 92037
1145
mi
from
La Jolla, CA
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Tufts Medical Center
800 Washington St
Boston, Massachusetts 02111
(617) 636-5000
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
1443
mi
from
Boston, MA
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Cedars-Sinai Medical Center
8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
1168
mi
from
Los Angeles, CA
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University of Michigan
500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
University of Michigan The University of Michigan was founded in 1817 as one of the...
808
mi
from
Ann Arbor, MI
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Emory University School of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine
Atlanta, Georgia 30322
?
mi
from
Atlanta, GA
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Georgia Regents Univ/ Augusta Univ
1430 John Wesley Gilbert Drive
Augusta, Georgia 30912
935
mi
from
Augusta, GA
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Piedmont Healthcare Pulm & Crit Care Research
3820 Medical Park Drive Southwest
Austell, Georgia 30106
787
mi
from
Austell, GA
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Johns Hopkins University School of Medicine
733 North Broadway
Baltimore, Maryland 21205
(410) 955-3182
Johns Hopkins University School of Medicine Johns Hopkins Medicine (JHM), headquartered in Baltimore, Maryland, is...
1149
mi
from
Baltimore, MD
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Boston University School of Medicine / Boston University Medical Center
Boston, Massachusetts 02118
1444
mi
from
Boston, MA
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Montefiore Medical Center-Weiler Division
Bronx, New York 10461
1295
mi
from
Bronx, NY
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Centro de Investigacion y Prevencion Cardiovascular (CIPREC)
Buenos Aires,
5602
mi
from
Buenos Aires,
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The Lindner Clinical Trial Center
Cincinnati, Ohio 45219
725
mi
from
Cincinnati, OH
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Ohio State University Medical Center
Columbus, Ohio 43210
809
mi
from
Columbus, OH
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UT Southwestern Medical Center at Dallas
Dallas, Texas 75390
349
mi
from
Dallas, TX
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Henry Ford Hospital
2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
841
mi
from
Detroit, MI
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Duke Univ Med Ctr
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
1052
mi
from
Durham, NC
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University of Texas-Houston Health Center Department of Pulmonary & Critical Care
Houston, Texas 77030
572
mi
from
Houston, TX
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Baylor College of Medicine, Houston Methodist Hospital
6550 Fannin Street
Houston, Texas 77030
572
mi
from
Houston, TX
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GLVA Healthcare Center
Los Angeles, California 90073
?
mi
from
Los Angeles, CA
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Kentuckiana Pulmonary Associates
Louisville, Kentucky 40202
657
mi
from
Louisville, KY
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University of Wisconsin Hospital-Department of Medicine
Madison, Wisconsin 53792
574
mi
from
Madison, WI
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St. Luke's Medical Center
Milwaukee, Wisconsin 53215
633
mi
from
Milwaukee, WI
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Froedtert Hospital, Pulm & Critical Care
9200 West Wisconsin Avenue
Milwaukee, Wisconsin 53226
631
mi
from
Milwaukee, WI
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Vanderbilt Medical Center
Nashville, Tennessee 37212
618
mi
from
Nashville, TN
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LSU Health Science Center - New Orleans
New Orleans, Louisiana 70112
697
mi
from
New Orleans, LA
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Columbia University Medical Center, Pediatric Cardiology
New York, New York 10032
1290
mi
from
New York, NY
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Christiana Care Health Services, Inc
Newark, Delaware 19713
1195
mi
from
Newark, DE
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Newark Beth Israel Medical Center
201 Lyons Ave
Newark, New Jersey 07112
(973) 926-7000
Newark Beth Israel Medical Center Newark Beth Israel Medical Center, a regional care, teaching hospital...
1278
mi
from
Newark, NJ
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Penn Presbyterian Medical Center
Philadelphia, Pennsylvania
1225
mi
from
Philadelphia, PA
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Thomas Jefferson University Hospital
111 S 11th St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Thomas Jefferson University Hospital Our hospitals in Center City Philadelphia share a 13-acre campus with...
1225
mi
from
Philadelphia, PA
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Oregon Pulmonary Associates, PC
Portland, Oregon 97225
?
mi
from
Portland, OR
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University of California, Davis, UC Davis Medical Center
Sacramento, California 95817
1281
mi
from
Sacramento, CA
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
414
mi
from
Saint Louis, MO
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LIU Center for Pulmonary Hypertension
Torrance, California 90502
1178
mi
from
Torrance, CA
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William Beaumont Hospital
Troy, Michigan 48085
844
mi
from
Troy, MI
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University of Arizona Clinical and Translational Science (CATS) Research Center
Tucson, Arizona 85724
833
mi
from
Tucson, AZ
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