Role of Inflammation in Progressive Multifocal Leukoencephalopathy (PML)

To determine precisely what are the host or viral factors that may predict a favorable
outcome for PML patients and the role of inflammation in preventing JCV from causing brain
disease. One of the goals of this study is to help establish non-invasive markers of PML
evolution by studying the brain metabolism in PML lesions using Magnetic Resonance Imaging
(MRI), Magnetic Spectroscopy (MRS) and other advanced imaging modalities.

Inclusion Criteria:

- PML patients of 18 years of age or older will be included in this study.

Exclusion Criteria:

1. Presence of opportunistic brain lesions other than PML. ( e.g., toxoplasmosis,
lymphoma)

2. Presence of confounding neurological disorder such as brain neoplasm etc.

In addition patients with a contraindication to MRI examination will be excluded from
study. Contraindications to the MRI examination include:

1. Medically unstable or hematological, renal, or hepatic dysfunction.

2. Cardiac pacemaker

3. Internal clips,

4. Metal implants, or external clips with 10 mm of the head.

5. Metal in the eyes.

6. Pregnant

7. Claustrophobia