Effect of Nebulized Bronchodilators on Heart Rate
| Status: | Completed |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Hospital |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | December 2008 |
| End Date: | November 2009 |
Prospective Trial of Effect of Nebulized Bronchodilators on Heart Rate and Arrhythmias in Critically Ill Adult Patients
The purpose of the study is to determine adverse events rates of nebulized albuterol versus
levalbuterol among adult critically ill patients and determine if a differential exists in
adverse events between the two drugs.
levalbuterol among adult critically ill patients and determine if a differential exists in
adverse events between the two drugs.
A randomized, single-blind, cross-over, prospective study was conducted in seventy
critically ill adult patients with acute air flow obstruction. Patients were randomized to
nebulized albuterol alternating with levalbuterol every 4 to 6 hours. Group A received
albuterol 2.5 mg alternating with levalbuterol 0.63 mg. Group B received albuterol 2.5 mg
alternating with levalbuterol 1.25 mg. All patients received nebulized ipratropium bromide
500 micrograms with each treatment. Heart rate and cardiac rhythm were continuously recorded
before and 15 minutes after finishing each treatment. Any new rhythm abnormalities between
treatments were also recorded.
critically ill adult patients with acute air flow obstruction. Patients were randomized to
nebulized albuterol alternating with levalbuterol every 4 to 6 hours. Group A received
albuterol 2.5 mg alternating with levalbuterol 0.63 mg. Group B received albuterol 2.5 mg
alternating with levalbuterol 1.25 mg. All patients received nebulized ipratropium bromide
500 micrograms with each treatment. Heart rate and cardiac rhythm were continuously recorded
before and 15 minutes after finishing each treatment. Any new rhythm abnormalities between
treatments were also recorded.
Inclusion Criteria:
- Adults who required inhaled bronchodilator therapy in the form of short acting beta
adrenergic receptor agonist and short acting anti-cholinergic treatment every 4-6
hours for respiratory functions
Exclusion Criteria:
- Known allergy or sensitivity to study medications
- Baseline heart rate was greater than 110 beats per minute
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Genesys Regional Medical Center Genesys Health System, a member of Ascension Health, is a group...
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