Evaluation of the Reproducibility of Jumping Mechanography
Status: | Completed |
---|---|
Conditions: | Orthopedic |
Therapuetic Areas: | Orthopedics / Podiatry |
Healthy: | No |
Age Range: | 70 - Any |
Updated: | 4/21/2016 |
Start Date: | May 2010 |
End Date: | March 2011 |
Evaluation of the Reproducibility of Jumping Mechanography in Older Adults and Comparison With Current Functional Assessment Tools
Sarcopenia, the age-related decline in muscle mass and function (widely recognized as
"frailty"), is increasingly being appreciated, primarily in the research environment.
Interventions to prevent or treat sarcopenia can be anticipated to reduce falls, fractures
and thereby to facilitate independence and improve quality of life for older adults.
Unfortunately, there is no current consensus definition of sarcopenia, thereby impeding
clinical recognition and treatment. It has been advocated that low appendicular (arm and
leg) lean mass, as measured by DXA, be utilized as a clinical diagnostic tool to define
sarcopenia. While such an approach is possible, however, muscle strength loss is more rapid
than mass loss, indicating deterioration of muscle "quality." Muscle quality may be affected
by changes at the neuromuscular, cellular or subcellular levels; parameters not detected by
measuring mass alone. Clearly, tools evaluating muscle performance, not simply mass, are
needed to optimally identify, and subsequently monitor, treatment of older adults with
sarcopenia. While current tests of muscle power/function (e.g., chair-rising, self-selected
gait velocity, etc.) do correlate with functional limitation in older adults, these existing
tests have limitations in that they cannot be performed in all people, may have "yes/no"
results rather than a continuous scale and may not be highly precise. Thus, improved muscle
function assessment tools are needed, both clinically and in research venues. Jumping
mechanography is very likely one such methodology.
"frailty"), is increasingly being appreciated, primarily in the research environment.
Interventions to prevent or treat sarcopenia can be anticipated to reduce falls, fractures
and thereby to facilitate independence and improve quality of life for older adults.
Unfortunately, there is no current consensus definition of sarcopenia, thereby impeding
clinical recognition and treatment. It has been advocated that low appendicular (arm and
leg) lean mass, as measured by DXA, be utilized as a clinical diagnostic tool to define
sarcopenia. While such an approach is possible, however, muscle strength loss is more rapid
than mass loss, indicating deterioration of muscle "quality." Muscle quality may be affected
by changes at the neuromuscular, cellular or subcellular levels; parameters not detected by
measuring mass alone. Clearly, tools evaluating muscle performance, not simply mass, are
needed to optimally identify, and subsequently monitor, treatment of older adults with
sarcopenia. While current tests of muscle power/function (e.g., chair-rising, self-selected
gait velocity, etc.) do correlate with functional limitation in older adults, these existing
tests have limitations in that they cannot be performed in all people, may have "yes/no"
results rather than a continuous scale and may not be highly precise. Thus, improved muscle
function assessment tools are needed, both clinically and in research venues. Jumping
mechanography is very likely one such methodology.
Inclusion Criteria:
- Ambulatory, community dwelling men and women age ≥ 70 years
- Able and willing to sign informed consent
- Able to stand without assistance
Exclusion Criteria:
- Abnormalities on screening laboratory assessment deemed to be clinically significant
by the study investigators
- History of myocardial infarction within the prior six months or ongoing angina
- History of injury or surgery within the prior six months which limits the ability to
ambulate
- History of severe end-organ disease, e.g., cardiovascular, hepatic, hematologic,
pulmonary, etc., which might limit the ability to complete this study
- History of malignancy with metastasis to the musculoskeletal system
- Neuromuscular disease impairing balance to the degree of not being able to stand
without assistance
- BMD T-score of less than -3.5 at any measured site and a prior hip or vertebral
fracture
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