A Study of Aleglitazar in Combination With Aspirin in Healthy Volunteers

Inclusion Criteria:

- Healthy volunteers, aged 40 to 65 years inclusive

- Body Mass Index (BMI) between 18 and 35 kg/m2 inclusive

- Females of child-bearing potential must be willing to use two acceptable methods of
contraception during the study and at least 3 months before start of the study

- Non-smoker or currently smoking less than 5 cigarettes (or equivalent amount of other
tobacco products) per day and is willing and able to stop smoking during the period
in study center

- Volunteer drinks no more than 3 cups of coffee, tea or soft drinks per day and is
willing and able to stop drinking coffee, tea and soft drinks during the period in
study center

Exclusion Criteria:

- Any clinically relevant abnormal laboratory test results at screening

- Volunteer has taken any prescribed, herbal or over-the-counter medication within 2
weeks prior to first dosing

- A history of any clinical significant gastro-intestinal, cardiovascular,
musculoskeletal, endocrine, hematological, psychiatric, renal, hepatic,
bronchopulmonary or neurological conditions or lipid disorders

- A positive test for human immunodeficiency virus (HIV-1 or HIV-2), hepatitis B or
hepatitis C

- History of intolerance to non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin,
history of gastric or duodenal ulceration, personal or family history of abnormal
clotting or bleeding