Can We Predict Who Has Gastroesophageal Reflux Disease (GERD)?
| Status: | Completed |
|---|---|
| Conditions: | Gastroesophageal Reflux Disease |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | November 2010 |
| End Date: | June 2015 |
Can We Predict Who Has GERD? Systematic Evaluation of Role of pH Monitoring and the Specific Physiologic pH Parameters in Defining GERD, Bravo, Impedence and SISAP
Gastroesophageal reflux disease (GERD) is currently defined as "a condition which develops
when the reflux of stomach contents causes troublesome symptoms and/or complications".
Doctors often diagnose and treat GERD based on symptoms of heartburn and regurgitation. In
recent years, the prevalence of partial or non-response to Proton Pump Inhibitors (PPI) has
increased resulting in diagnostic testing with esophagogastroduodenoscopy (EGD) or
ambulatory pH monitoring. Most patients do not have endoscopic evidence for reflux. Thus, in
this group pH monitoring has emerged as an important physiologic test to determine the
degree of esophageal acid exposure and to assess the association between patients'
persistent symptoms and acid reflux events. The aims of this study are to assess the
sensitivity and specificity of symptom associated indices and determine the best parameter
for predicting GERD from a list of conventional pH measurement findings.
when the reflux of stomach contents causes troublesome symptoms and/or complications".
Doctors often diagnose and treat GERD based on symptoms of heartburn and regurgitation. In
recent years, the prevalence of partial or non-response to Proton Pump Inhibitors (PPI) has
increased resulting in diagnostic testing with esophagogastroduodenoscopy (EGD) or
ambulatory pH monitoring. Most patients do not have endoscopic evidence for reflux. Thus, in
this group pH monitoring has emerged as an important physiologic test to determine the
degree of esophageal acid exposure and to assess the association between patients'
persistent symptoms and acid reflux events. The aims of this study are to assess the
sensitivity and specificity of symptom associated indices and determine the best parameter
for predicting GERD from a list of conventional pH measurement findings.
Inclusion Criteria:
- Male and female subjects ages 18 or older
- Presenting to the Vanderbilt GI outpatient clinic with symptoms of GERD
- Undergoing upper endoscopy and wireless pH monitoring (standard of care)
- Erosive disease: presence of esophageal mucosal injuries documented
- Non-erosive disease: normal esophagogastroduodenoscopy (EGD) with symptoms
- Control group: normal subjects without symptoms of GERD
Exclusion Criteria:
- Anti-reflux therapy within 7 days prior to the pH study
- Previous neck, esophagus, or stomach surgery
- Major motility disorders
- Previous neck, esophagus, or stomach cancer or radiations
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