A Safety and Efficacy Study of Farletuzumab in Subjects With Adenocarcinoma of the Lung



Status:Completed
Conditions:Lung Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:April 2011
End Date:November 2013

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-Blind, Placebo-Controlled, Study of the Safety and Efficacy of Farletuzumab in Combination With a Platinum Containing Doublet in Chemotherapy-Naїve Subjects With Stage IV Adenocarcinoma of the Lung

This randomized, placebo-controlled, multicenter study will test the hypothesis that
farletuzumab can add to the efficacy of a platinum containing doublet in Stage IV
adenocarcinoma of the lung.


Inclusion Criteria:

- Histologically or cytologically confirmed adenocarcinoma of the lung classified as
stage IV

- Confirmed folate receptor-alpha (FRA) expression by IHC

- Measurable disease with at least one unidimensionally measurable lesion according to
RECIST criteria version 1.1 by CT or MRI scans (CT or MRI scans must have been
performed within 30 days prior to the first dose of farletuzumab or placebo)

- Must have received no prior chemotherapy, radiation therapy or surgery with curative
intent for adenocarcinoma of the lung

Exclusion Criteria:

- Subjects who have had previous chemotherapy for adenocarcinoma of the lung

- Prior surgery with curative intent for adenocarcinoma of the lung

- Prior radiotherapy for adenocarcinoma of the lung. (Prior treatment with local
radiotherapy for symptom control [i.e., palliative radiation with non-curative
intent] is permitted)
We found this trial at
55
sites
Pacific Hematology Oncology Associates
San Francisco, California 94115
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Center for Hematology Oncology
Boca Raton, Florida 33486
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Boca Raton, FL
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University of Texas Medical Branch
301 University Blvd
Galveston, Texas 77555
(409) 772-1011
University of Texas Medical Branch Established in 1891 as the University of Texas Medical Department,...
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Galveston, TX
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M.D. Anderson Cancer Center at Orlando
1400 South Orange Avenue
Orlando, Florida 32806
(407) 648-3800
M.D. Anderson Cancer Center at Orlando For more than twenty years, our cancer center has...
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Orlando, FL
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Christus Saint Frances, Cabrini Hospital, Cabrini Cancer Center
Alexandria, Louisiana 71301
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Alexandria, LA
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Texas Oncology, P.A. - Bedford
Bedford, Texas 76022
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Bedford, TX
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National Cancer Institute
Bethesda, Maryland
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Bethesda, MD
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St. Luke's Cancer Center Associates
Bethlehem, Pennsylvania 18015
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Bethlehem, PA
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Providence Health System
Beverly Hills, California 90210
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Beverly Hills, CA
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University Hematology Oncology, Inc
Centralia, Illinois 62801
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Centralia, IL
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Ironwood Cancer and Research Center
Chandler, Arizona 85224
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Chandler, AZ
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University of Chicago Medical Center
5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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Chicago, IL
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Maryland Oncology Hematology PA
Columbia, Maryland 21044
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Columbia, MD
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Medical Specialists of the Palm Beaches
Deerfield Beach, Florida 33441
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Deerfield Beach, FL
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Rocky Mountain Cancer Centers, LLP
Denver, Colorado 80218
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Denver, CO
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Englewood Hospital and Medical Center
350 Engle St
Englewood, New Jersey 07631
(201) 894-3000
Englewood Hospital and Medical Center Englewood Hospital was incorporated in 1888 as a non-profit, non-sectarian...
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Englewood, NJ
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Willamette Valley Cancer Institute/Research Ctr
Eugene, Oregon 97401
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Eugene, OR
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Deaconess Clinic Downtown
Evansville, Indiana 47713
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Evansville, IN
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Virginia Cancer Specialists, PC
8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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Fairfax, VA
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Detroit Clinical Research Center PC
Farmington Hills, Michigan 48334
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Farmington Hills, MI
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Broward General Medical Center
Fort Lauderdale, Florida 33316
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Fort Lauderdale, FL
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Cancer Care Associates of Fresno Medical Group Inc
Fresno, California 93720
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Fresno, CA
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Gettysburg Cancer Center
Gettysburg, Pennsylvania 17325
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Gettysburg, PA
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Medical Oncology Hematology
Gilroy, California 95020
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Gilroy, CA
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Arizona Center for Hematology Oncology
Glendale, Arizona 85306
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Glendale, AZ
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Cancer TEAM Bellin Health
Green Bay, Wisconsin 54313
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Green Bay, WI
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California Cancer Care
Greenbrae, California 94904
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Greenbrae, CA
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Kentucky Cancer Center
Hazard, Kentucky 41701
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Hazard, KY
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Houston Cancer Institute
1098 Hermann Drive
Houston, Texas 77055
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Houston, TX
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Queens Hospital Center
Jamaica, New York 11432
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Jamaica, NY
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Moores University of California San Diego Cancer Center
La Jolla, California 92093
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La Jolla, CA
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Wilshire Medical Oncology Group
La Verne, California 91750
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La Verne, CA
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Cancer Care of North Florida, P.A.
Lake City, Florida 32024
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Lake City, FL
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Baptist Health System, Inc.
Lexington, Kentucky 40503
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Lexington, KY
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Glendale Adventist Medical Center
Los Angeles, California 90033
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Los Angeles, CA
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Hematology and Oncology Specialists
Metairie, Louisiana 70006
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Metairie, LA
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Clinical Trials and Research Associates, Inc.
Montebello, California 90640
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Montebello, CA
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Community Hospital
Munster, Indiana 46321
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Munster, IN
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Tennessee Oncology, PLLC
250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
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Florida Cancer Institute- New Hope
New Port Richey, Florida 34655
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New Port Richey, FL
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Ocala Oncology Center Pl
Ocala, Florida 34474
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Ocala, FL
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North Country Oncology-Hematology
Oceanside, California 92056
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Oceanside, CA
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Berkshire Hematology Oncology, PC
Pittsfield, Massachusetts 01201
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Pittsfield, MA
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Texas Oncology-Plano East
Plano, Texas 75075
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Plano, TX
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Delta Hematology Oncology Associates, PC
Portsmouth, Virginia 23704
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Portsmouth, VA
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Central Coast Medical Oncology
Santa Maria, California 93454
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Santa Maria, CA
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Virginia Mason Medical Center
Seattle, Washington 98101
(888) 862-2737
Virginia Mason Medical Center Established in 1920, Virginia Mason began as an 80-bed hospital with...
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Rockwood Cancer Treatment Center
Spokane, Washington 99204
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Spokane, WA
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Medical Oncology Associates PS
Spokane, Washington 99208
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Spokane, WA
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Hematology Oncology Associates, PC
Stamford, Connecticut 06902
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Northwest Cancer Center
Sugar Land, Texas 77479
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Sugar Land, TX
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Syracuse Veterns Affairs Medical Center
Syracuse, New York 13210
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Syracuse, NY
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The Tweed Hospital
Tweed Heads, New South Wales 2485
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Tweed Heads,
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Texas Oncology-Tyler
Tyler, Texas 75702
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Tyler, TX
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Texas Oncology-Waco
Waco, Texas 76712
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