Reduction of IgE Antibody in Human Allergic Subjects

Allergic Rhinitis (Hay fever) affects many children and adults and is a risk factor for
development of asthma. This study utilizes the neurotransmitter, substance P, a small
molecule which is present in nerve endings, the brain, skin, lungs and the gastrointestinal
tract. Subjects will receive substance P and a low dosage of an allergen, such as ragweed in
an attempt to reduce allergic reactivity.

Inclusion Criteria:

- positive immediate type skin test to ragweed or grass pollen or a third (standardized)
allergen if both ragweed and grass pollen allergen are not positive

- volunteers should be available for allergen injections and then cutaneous titrations
for approximately 1 year from the start of the enrollment period

Exclusion Criteria:

- volunteer is pregnant or lactating

- abnormal electrocardiogram for subjects over 50 years of age

- use of beta adrenergic antagonists or tricyclic antidepressants