Does Gender Play a Role in Bone-mineral Density Measurement Precision?
| Status: | Completed |
|---|---|
| Conditions: | Osteoporosis |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 65 - Any |
| Updated: | 4/21/2016 |
| Start Date: | July 2010 |
| End Date: | January 2011 |
Bone mineral density (BMD) measurement using dual-energy x-ray absorptiometry (DXA) is the
current gold standard for osteoporosis diagnosis and therapy monitoring. Like all
quantitative tests, there is some variability in BMD results obtained when scanning a person
more than once. As such, it is current clinical practice, based on the recommendation of the
International Society for Clinical Densitometry, that each technologist perform a precision
assessment. This approach consists of scanning 30 people twice; the data from which allow
determination of what constitutes a real difference in BMD with 95% confidence. A precision
assessment typically evaluates a specific clinic's population, using the age range and
genders seen at that clinic. However men generally have larger, but often more arthritic,
bones than women which may impact the precision results. Therefore, it is possible that
gender-specific precision values should be used in clinical practice, however this issue has
never been investigated.
current gold standard for osteoporosis diagnosis and therapy monitoring. Like all
quantitative tests, there is some variability in BMD results obtained when scanning a person
more than once. As such, it is current clinical practice, based on the recommendation of the
International Society for Clinical Densitometry, that each technologist perform a precision
assessment. This approach consists of scanning 30 people twice; the data from which allow
determination of what constitutes a real difference in BMD with 95% confidence. A precision
assessment typically evaluates a specific clinic's population, using the age range and
genders seen at that clinic. However men generally have larger, but often more arthritic,
bones than women which may impact the precision results. Therefore, it is possible that
gender-specific precision values should be used in clinical practice, however this issue has
never been investigated.
Inclusion Criteria:
- Age ≥ 65 years
- Able and willing to sign informed consent
Exclusion Criteria:
- Inability to have DXA scans performed due to weight ≥ 450 pounds (exceeds
densitometer table limit)
- Metallic hardware in, or overlaying, any of the measured skeletal sites
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