Using Magnetic Resonance (MR) to Understand the Effect of Erythromycin on Bowel Motility
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 4/21/2016 |
| Start Date: | June 2011 |
| End Date: | March 2012 |
Magnetic Resonance (MR) Evaluation of the Effect of Erythromycin Upon Gastric and Small Bowel Motility
Magnetic Resonance Imaging (MRI) has proven to be a valuable imaging technique for suspected
small bowel disease. This technique depends, in part, on adequate distension of the small
bowel. This is accomplished by administering large volumes of a non-absorbable oral contrast
material prior to the examination, which typically produces excellent distension of the
distal small bowel and stomach, but poor distension of the proximal small bowel.
Erythromycin is a common antibiotic that is known to promote stomach emptying and is used to
treat diabetics with gastroparesis (poor stomach emptying.) The hypothesis of this study was
that erythromycin will increase gastric emptying and hence improve small and large
intestinal distention during MRI.
small bowel disease. This technique depends, in part, on adequate distension of the small
bowel. This is accomplished by administering large volumes of a non-absorbable oral contrast
material prior to the examination, which typically produces excellent distension of the
distal small bowel and stomach, but poor distension of the proximal small bowel.
Erythromycin is a common antibiotic that is known to promote stomach emptying and is used to
treat diabetics with gastroparesis (poor stomach emptying.) The hypothesis of this study was
that erythromycin will increase gastric emptying and hence improve small and large
intestinal distention during MRI.
Gastric, small, and large intestinal volumes were assessed with MRI after ingestion of a low
concentration of barium sulfate solution (1350 mL) and randomization to erythromycin 200 mg
i.v.) or placebo in 40 healthy volunteers. Magnetic Resonance Images of the abdomen were
acquired with a torso phased array coil and a 1.5 tesla magnet.
concentration of barium sulfate solution (1350 mL) and randomization to erythromycin 200 mg
i.v.) or placebo in 40 healthy volunteers. Magnetic Resonance Images of the abdomen were
acquired with a torso phased array coil and a 1.5 tesla magnet.
Inclusion Criteria:
- Normal healthy adult volunteers without known gastrointestinal disease
- Aged 18-70 years
- Able to provide written informed consent before participating in the study
- Able to communicate adequately with the investigator and to comply with the
requirements for the entire study.
Exclusion Criteria:
- Known allergy to erythromycin;
- Use of drugs that have known contraindication with erythromycin (concomitant therapy
with astemizole, cisapride, pimozide, or terfenadine)
- Corrected QT interval on EKG >460 msec
- Certain medications (i.e., theophylline, digoxin, oral anti-coagulant,
benzodiazepine, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors)
will either be excluded from the study or, if medically safe, will be asked to
discontinue the medication for 4 half-lives before beginning the study.
- Use of medications that alter GI motility e.g., narcotics, medications with
significant anticholinergic effects
- Pregnant or breast-feeding females
- Known claustrophobia
- Known family history of sudden death or congenital QT prolongation
- Presence of pacemaker, internal defibrillator, or other non-MR compatible device
- Patients with known metal present within their abdomen
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