Long-Term Effects of Treatment in Patients Previously Treated for Childhood Hodgkin's Lymphoma

OBJECTIVES:

- Determine the cumulative incidence and characterize the spectrum of selected adverse
physiologic and psychosocial outcomes, using self-report and clinical evaluation, in
patients previously treated for childhood Hodgkin's lymphoma.

- Compare the cumulative incidence and spectrum of self-reported adverse outcomes of these
patients, using data collected at a comparable time period after diagnosis, with
Hodgkin's lymphoma survivors from the Childhood Cancer Survivor Study (CCSS).

- Compare self-reported health-related outcomes with outcomes detected by clinical
evaluation and medical record review of each group of patients.

OUTLINE: This is a cohort, cross-sectional, multicenter study.

- Contemporary group: Patients complete a self-report of long-term outcomes questionnaire
and a comprehensive psychosocial questionnaire. A medical record review is then
performed. Patients then undergo a comprehensive risk-based clinical evaluation with
specific examinations and studies based upon the Children's Oncology Group Late Effects
Screening Guidelines and the patients' specific therapeutic exposures.

- Childhood Cancer Survivor Study (CCSS) group: Patients undergo a telephone interview and
have medical records reviewed to validate select self-reported long-term outcomes.
Patient replies from the baseline CCSS questionnaire (which was completed at certain
timepoints after diagnosis) are reviewed for targeted long-term outcomes.

PROJECTED ACCRUAL: Approximately 1,000 patients will be accrued for this study.

DISEASE CHARACTERISTICS:

- Contemporary cohort

- At least 5 years since diagnosis of Hodgkin's lymphoma

- Diagnosed between the years 1987-2001

- 21 and under at diagnosis

- No evidence of disease

- Prior treatment on 1 of the following protocols during the years 1987-2001:

- Children's Cancer Group (CCG) CCG-5942, CCG-59704

- Pediatric Oncology Group (POG) POG-8625, POG-8725, POG-9425, POG-9426

- Pediatric Hodgkin's Consortium: VAMP, VEPA, VAMP/COP

- Institutional protocols COPP/ABV, MOPP/ABVD, ABVD

- Childhood Cancer Survivor Study (CCSS) Hodgkin's lymphoma cohort

- Current enrollment in the CCSS

- Diagnosed between the years 1976-1986

- Completed baseline questionnaire at comparable timepoints (as the contemporary
cohort) after diagnosis

PATIENT CHARACTERISTICS:

Age

- Any age

Performance status

- Not specified

Life expectancy

- Not specified

Hematopoietic

- Not specified

Hepatic

- Not specified

Renal

- Not specified

PRIOR CONCURRENT THERAPY:

Biologic therapy

- Not specified

Chemotherapy

- Not specified

Endocrine therapy

- Not specified

Radiotherapy

- Not specified

Surgery

- Not specified