Collecting Bone Graft During Spinal Decompression and Posterolateral Lumbar Fusion to Better Define Bone Making Cells
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/31/2019 |
| Start Date: | October 2011 |
| End Date: | January 2020 |
Defining the Osteogenic Potential of Mesenchymal Stem Cells and Their Progenitors During Spinal Decompression and Posterolateral Lumbar Fusion
The purpose of this study is to improve fusion (bony healing) techniques and improve patient
recovery by identifying cells in your body that make bone. Patients with spine problems often
need surgeries that include fusion (bony healing) of vertebrae (bones in your back) together
in order to hold the bones steady allowing them to heal together (fusion). If the vertebrae
(back bones) fail to heal together, which occurs about 10-15% of the time, it can result in a
slower recovery and may require revision (another) surgery. By using a small portion of the
graft taken during surgery the investigators hope to define the cells that make bone most
efficiently. This will help reduce the need for revision surgeries and improve patient
recovery.
recovery by identifying cells in your body that make bone. Patients with spine problems often
need surgeries that include fusion (bony healing) of vertebrae (bones in your back) together
in order to hold the bones steady allowing them to heal together (fusion). If the vertebrae
(back bones) fail to heal together, which occurs about 10-15% of the time, it can result in a
slower recovery and may require revision (another) surgery. By using a small portion of the
graft taken during surgery the investigators hope to define the cells that make bone most
efficiently. This will help reduce the need for revision surgeries and improve patient
recovery.
This study requests using your additional bone tissue (the extra tissue not needed after your
back surgery is complete).
This tissue will be measured for total volume (amount), labeled with your age, gender, date
and time the tissue was removed (date and time of surgery), and taken to a lab for analysis.
You will not be billed for the collection of your additional tissue or the lab analysis. All
routine procedures (surgery and all follow-up care relating to your back surgery) will still
be paid for by you or your insurance.
Once your extra tissue sample has been collected, measured, labeled, and sent to the lab for
testing, no further participation is required from you in this research study. The
investigators will use your sample in our research to enhance bone healing.
back surgery is complete).
This tissue will be measured for total volume (amount), labeled with your age, gender, date
and time the tissue was removed (date and time of surgery), and taken to a lab for analysis.
You will not be billed for the collection of your additional tissue or the lab analysis. All
routine procedures (surgery and all follow-up care relating to your back surgery) will still
be paid for by you or your insurance.
Once your extra tissue sample has been collected, measured, labeled, and sent to the lab for
testing, no further participation is required from you in this research study. The
investigators will use your sample in our research to enhance bone healing.
Inclusion Criteria:
- Patients electing to undergo spinal decompression with an instrumented posterolateral
fusion
Exclusion Criteria:
- Patients not undergoing spinal decompression with an instrumented posterolateral
fusion
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