Study of Proteins in Tumor Samples From Patients With Non-Small Cell Lung Cancer
| Status: | Withdrawn |
|---|---|
| Conditions: | Lung Cancer, Lung Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/26/2019 |
| Start Date: | October 2011 |
| End Date: | August 2015 |
Evaluation of a Novel Molecular NSCLC Classification System
This research studies protein in tumor samples from patients with non-small cell lung cancer.
Finding specific proteins in tumor tissue samples from patients with cancer may help doctors
tell what type of lung cancer a patient has and plan better treatment.
Finding specific proteins in tumor tissue samples from patients with cancer may help doctors
tell what type of lung cancer a patient has and plan better treatment.
PRIMARY OBJECTIVES:
I. To validate a novel 4-protein signature's ability to subtype non-small cell lung cancer
(NSCLC) in a treatment-naive, multi-institutional cohort, Cancer and Leukemia Group B (CALGB)
9761.
SECONDARY OBJECTIVES:
I. To estimate the NSCLC misclassification rate in a multi-institutional clinical-trial
setting for stage 1 NSCLC (adenocarcinoma versus squamous cell).
OUTLINE:
Previously collected tissue samples are analyzed via hematoxylin and eosin (H&E) staining and
immunohistochemistry (IHC).
I. To validate a novel 4-protein signature's ability to subtype non-small cell lung cancer
(NSCLC) in a treatment-naive, multi-institutional cohort, Cancer and Leukemia Group B (CALGB)
9761.
SECONDARY OBJECTIVES:
I. To estimate the NSCLC misclassification rate in a multi-institutional clinical-trial
setting for stage 1 NSCLC (adenocarcinoma versus squamous cell).
OUTLINE:
Previously collected tissue samples are analyzed via hematoxylin and eosin (H&E) staining and
immunohistochemistry (IHC).
Inclusion Criteria:
- Patients must have been registered on CALGB-9761
- Stage I disease
- Treatment-naive patients
- A representative paraffin block of the primary tumor must be available from patients
on CALGB-9761 and submitted to the CALGB Pathology Coordinating Office
- A separate consent form is not required for this study, as permission for research to
be performed on the tissue blocks is included in the consent form for CALGB 9761
- Institutional review board (IRB) review and approval at the institution where the
laboratory work will be performed is required
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