Prediabetes, Prehypertension and Vitamin D Supplementation - A Practice Based Clinical Intervention Pilot Study

Study visits will measure temperature, fasting glucose, resting blood pressure, respiratory
rate, height, weight and waist circumference. A brief medical History will be taken,
followed by an abbreviated physical exam. A blood test to check your vitamin D level and
routine chemistry including a complete lipid profile, liver and kidney function will be
completed.

Based on your fasting glucose and/or resting blood pressure you will be in one of the three
arms: prediabetes (arm 1), prehypertension (arm 2) or co-existing prediabetes and
prehypertension (arm 3). After determining the arm of the study you are in, you will be
randomly assigned to receive either a placebo or vitamin D supplementation.

If you are in the first arm with prediabetes (fasting glucose 100-125 mg/dL), the primary
outcome measure will change in fasting glucose at 8 weeks, 16 weeks and every 3 months until
you are in the study up to 5 years. If you are in the second arm with prehypertension
(resting blood pressure 120-139/80-89 mm Hg), the primary outcome measure will change in
resting blood pressure at 8 weeks, 16 weeks and every 3 months until you are in the study up
to 5 years. If you are in third arm with prediabetes and prehypertension, both these
measures will be taken at 8 weeks, 16 weeks and every 3 months until you are in the study up
to 5 years. A repeat blood test to check vitamin D levels will be done at 8 and 16 weeks
(and periodically as necessary) during the study.

Other measures will be taken as are routine in your doctor's office.

Inclusion Criteria:

- Healthy Male or Female 18 years or older presenting to The America Family Practice,
Physicians Care Center offices or Egan Wellness Clinic/Anti-Aging & Skin Care Spa.

- Agreeable to treatment with placebo or vitamin D 1000IU twice a day with food.

Exclusion Criteria:

- Women who are pregnant or nursing

- Anyone with chronic medical conditions requiring regular intake of any prescription
medications.