Safety Study of INX-08189, Pharmacokinetic and Pharmacodynamic With Ribavirin and Food Effect Study, in Chronically-infected Genotype 1 Hepatitis C Virus, Treatment-naïve Subjects

Primary Objectives:

To evaluate in chronically-infected, non-cirrhotic, genotype 1 treatment naïve-subjects
dosed with Study Drug for 7 consecutive days

Safety

- The safety of each of the 4 dosing cohorts of INX-08189 (200 mg daily (QD), 100 mg twice a
day (BID), 100 mg QD with low-fat meal, and 100 mg QD with adjunctive ribavirin).

Pharmacokinetic

- To characterize the pharmacokinetic (PK) profile of oral doses of INX-08189 (200 mg QD,
100 mg BID, 100 mg QD with low-fat meal, and 100 mg QD with adjunctive ribavirin) and the PK
profile of the metabolite (INX-08032).

Pharmacodynamic

- To evaluate the relationship between the kinetics of the reduction from baseline in serum
HCV RNA and PK parameters of INX-08189 and the metabolite INX-08032

Efficacy

- To measure the kinetics of viral load reduction in plasma HCV RNA by each of the 4 dosing
cohorts of INX-08189 (200 mg QD, 100 mg BID, 100 mg QD with low-fat meal, and 100 mg QD with
adjunctive ribavirin).

Inclusion Criteria:

Screening visit (Visit 1), subject criteria:

- Males and females, 18 to 65 years of age inclusive with a body mass index (BMI) of at
least 18 kg/m2 but not exceeding 36 kg/m2;

- Diagnosed with chronic HCV by at least 1 previous polymerase chain reaction (PCR)
result prior to Visit 1 (screening), with a positive HCV viral load of least 100,000
IU/ml at Visit 1 (screening) as measured by quantitative PCR;

- HCV genotype 1 per laboratory testing report;

- HCV treatment-naïve where "treatment-naïve" is defined as no prior treatment with
interferon alpha, pegylated interferon alpha, ribavirin, or any HCV direct acting
anti-viral drugs;

- Liver biopsy consistent with chronic HCV infection but with a classification of
non-cirrhotic as judged by a pathologist (defined as Knodell ≤ 3, Metavir ≤ 2, Ishak
≤ 4, or Batts & Ludwig ≤ 2) within the last 2 years and before Visit 2 (biopsy can be
done within the screening period);

- Negative urine drug screen for drugs of abuse (see Appendix B; note: methadone is not
allowed);

- Females will have a negative serum beta human chorionic gonadotropin (βHCG) pregnancy
test at screening and a negative urine dipstick pregnancy test upon entry to the
clinical unit on Study Day -1;

- Agreement by both female subjects of childbearing potential and male subjects (who
have not been surgically sterilized) to practice an acceptable method of birth
control, which includes at least 1 barrier during the study and at least 6 months
after cessation of treatment. Surgical sterilization of either the female or the male
must have occurred at least 6 month prior to first dose and females must be
post-menopausal for 2 years to be considered non-child-bearing potential.

- Willing and able to complete all study visits and procedures, and able to effectively
communicate with the Investigator and other testing center personnel;

- Signed informed consent form (ICF) executed prior to protocol screening assessments

Exclusion Criteria:

screening visit (Visit1), subject criteria:

- Advanced liver disease, cirrhosis, or signs of decompensated liver disease such as
variceal bleeding, ascites, hepatic encephalopathy, active jaundice defined by a
total bilirubin > 2, or other evidence of decompensated liver disease;

- Co-infection with hepatitis B virus (HBV)or human immunodeficiency virus (HIV)
(positive test for hepatitis B surface antigen [HBsAg] or anti-HIV antibody [Ab]);

- Acute cardiac ischemia, unstable heart disease or clinically symptomatic cardiac
abnormalities apparent on electrocardiogram (ECG) and physical exam, or a QTcF
interval at Visit 1 of ≥ 450 ms by Fridericia's correction, or a personal or family
history of Torsades de pointes;

- Use of the following medications concurrently or within the 30 days prior Screening
(Visit 1) associated with QT prolongation: macrolides, antiarrhythmic agents, azoles,
fluoroquinolones, and tricyclic anti-depressants (note: methadone use is not
allowed);

- Use of immunosuppressive or immune-modulating agents (including corticosteroids and
immunosuppressive agents) or presence of an immunologically-mediated autoimmune
disease (other than asthma) or history of solid organ or bone marrow transplantation
(note: inhaled steroids for asthma and topical steroid for minor skin conditions
allowed and washout period for PO/IM/IV corticosteroid use is 8 weeks; washout
periods for other immunosuppressives determined by Medical Monitor);

- Use of strong Cytochrome P (CYP)3A4-inhibiting protease inhibitors (specifically
atazanavir, indinavir, nelfinavir, saquinavir, and ritonavir), strong CYP3A4
inhibitors (specifically clarithromycin, itraconazole, ketoconazole, nefazodone,
telithromycin), or strong CYP3A4 inducers (specifically rifampin, efavirenz,
etravirine, phenobarbital, phenytoin, and carbamazepine);

- Absolute neutrophil count of < 1,800 cells/mm3, or platelet count < 130,000
cells/mm3, or hemoglobin < 12 g/dl for women and < 13 g/dl for men, or a history of
anemia, sickle cell anemia, or thalassemia; (note: if baseline value within 5% of
minimum qualifying value, 1 re-test allowed for the purpose of qualifying for study);

- A history of abnormal thyroid function that is not adequately controlled (defined as
thyroid stimulating hormone [TSH] levels < 0.8 x lower limit of normal [LLN] or > 1.2
x the upper limit of normal [ULN]);

- Serum creatinine concentration ≥ 1.5 times the upper limit of normal, or albumin ≤ 3
g/dl;

- Any history of suicide attempt, receipt of professional counseling for suicidal
ideation or any current suicidal ideation, or other serious psychiatric disorders
(ie, bipolar disorder, severe depression, psychosis) requiring or having required
hospitalization or medication

- Any malignancy within the last 5 years other than treated cervical carcinoma in situ
or treated basal cell carcinoma with no more than 20% risk of recurrence within 2
years;

- Alcohol abuse within the past 2 years or an alcohol use pattern that will interfere
with the study conduct;

- Drug abuse within the last 6 months.

- Current lactation or breastfeeding;

- Major surgery within 30 days prior Visit 1;

- Participation in another clinical trial of an investigational drug or device within 6
months prior to visit 1 unless that prior participation involved exposure only to
placebo by clear and available documentation;

- Donation of blood or plasma within 30 days prior to Visit 1.