A Continuous, Non-Invasive, Real-time Method for Estimating and Predicting Intracranial Hypertension
| Status: | Active, not recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | 18 - 89 |
| Updated: | 12/29/2018 |
| Start Date: | August 2011 |
| End Date: | November 2019 |
There is statistically significant correlation between invasive measures of intracranial
pressure (ICP) and non-invasive, real-time, continuous physiologic waveform data algorithms
to predict ICP. Furthermore, characteristics within this physiologic waveform data will allow
modeling for trend prediction of derived ICP information. Specific aims:
1. Develop models to estimate ICP and cerebral perfusion pressure (CPP) after traumatic
brain injury in humans.
2. Predict and anticipate changes in ICP for preemptive management purposes.
3. Analyze characteristics of changes in ICP after treatment failure.
4. Analyze data to predict/anticipate confounding physiologic factors that affect ICP and
its treatment.
5. Test the resulting models in real time.
pressure (ICP) and non-invasive, real-time, continuous physiologic waveform data algorithms
to predict ICP. Furthermore, characteristics within this physiologic waveform data will allow
modeling for trend prediction of derived ICP information. Specific aims:
1. Develop models to estimate ICP and cerebral perfusion pressure (CPP) after traumatic
brain injury in humans.
2. Predict and anticipate changes in ICP for preemptive management purposes.
3. Analyze characteristics of changes in ICP after treatment failure.
4. Analyze data to predict/anticipate confounding physiologic factors that affect ICP and
its treatment.
5. Test the resulting models in real time.
Inclusion Criteria:
- patients with severe traumatic brain injury resulting in motor Glasgow Coma Score
(GCS) score < 5
- age 18-89 years
- health care provider indicating the need for hyperosmolar therapy for elevated ICP
Exclusion Criteria:
- pregnancy
- incarceration
- brain death (GCS 3 with fixed, dilated pupils)
- life-threatening systemic injuries (Abbreviated Injury Scale (AIS) >4 in an organ
system other than CNS)
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