Study to Determine the Effect of Ketoconazole on the Pharmacokinetics of GDC-0980

Inclusion Criteria:

- Healthy postmenopausal and/or surgically sterile adult nonsmoking female subject
between 18 and 65 years of age, inclusive, with a body mass index of 18 to 32 kg/m2,
inclusive

- Medically healthy as determined by the absence of clinically significant findings in
the physical examination, medical history, vital sign measurements, clinical
laboratory tests, or 12 lead electrocardiograms (ECGs) as determined by the
investigator

- Female subject of nonchildbearing potential

Exclusion Criteria:

- History or clinical manifestations of significant metabolic (including type 1 and 2
diabetes), hepatic, renal, hematological (including hypercholesterolemia and
triglyceridemia), pulmonary, cardiovascular, endocrine, gastrointestinal (including
gastric or duodenal ulcers), urological, neurological, or psychiatric disorders, or
cancer

- History of inflammatory arthritis

- History of symptomatic hypotension

- History of severe physical injury, direct impact trauma, or neurological trauma
within 6 months before Day 1 of Period 1

- History of seizure disorders

- History of bipolar or major depressive disorder

- History of stomach or intestinal surgery or resection that could potentially alter
absorption and/or excretion of orally administered drugs, with the exception of
appendectomy, hernia repair, and cholecystectomy, which are allowed

- History of active liver disease, including hepatitis or cirrhosis

- History or presence of an abnormal ECG

- History of ventricular dysrhythmias or risk factors for ventricular dysrhythmias

- Abnormality on the chest x-ray at Screening determined to be clinically significant
by the investigator and medical monitor

- History of alcoholism, drug abuse, or drug addiction

- Used any nicotine-containing or nicotine-replacement products within 6 months before
Day 1 of Period 1

- Participated in any other investigational drug study in which receipt of an
investigational study drug occurred within 1 month or 5 half-lives before Day 1 of
Period 1

- Used any prescription medications/products including monoamine oxidase inhibitors,
thioridazine, pimozide, or antidepressants within 1 month (2 weeks for antibiotics)
before Day 1 of Period 1, with the exception of hormone replacement therapy or 2
weeks' use of narcotics for pain, unless deemed acceptable by the investigator

- Used medications capable of inhibiting hepatic enzymes within 1 month or 5 half-lives
before Day 1 of Period 1

- Received any vaccination or immunization within 1 month before Day 1 of Period 1

- Used proton pump inhibitors or histamine H2 receptor antagonists within 1 month
before Day 1 of Period 1

- Known hypersensitivity to ketoconazole, or other azole antifungals

- Used any over-the-counter, nonprescription preparations within 7 days before Day 1 of
Period 1, unless deemed acceptable by the investigator

- Used alcohol-containing, grapefruit-containing, or caffeine containing foods or
beverages within 72 hours before Day 1 of Period 1, unless deemed acceptable by the
investigator

- Poor peripheral venous access

- Donated blood within 2 weeks or plasma within 1 week before Day 1 of Period 1

- Received blood products within 2 months before Day 1 of Period 1

- Positive urine drug or alcohol screen

- Positive screen for hepatitis B surface antigen, hepatitis C virus, or human
immunodeficiency virus types 1 and 2

- Diagnosed with a vitamin B12 deficiency

- Any acute or chronic condition that, in the opinion of the investigator, would limit
the subject's ability to complete or participate in this clinical study