RYGB and the Gastric Adipose Axis
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 5/23/2018 |
| Start Date: | January 2012 |
| End Date: | July 2015 |
RYGB Improves Metabolism by Interrupting the Gastric Adipose Tissue Axis
The purpose of this study is to determine if interruption in gastric-adipose tissue axis
signaling contributes to early improvements in oxidative stress, insulin sensitivity, and
inflammation, and to determine if interruption of the stomach in RYGB results in reduction of
plasma acylated ghrelin (AG) and in an altered acylated ghrelin:unacylated ghrelin (AG:UAG)
ratio which may contribute to decreased oxidative stress and improved insulin sensitivity.
signaling contributes to early improvements in oxidative stress, insulin sensitivity, and
inflammation, and to determine if interruption of the stomach in RYGB results in reduction of
plasma acylated ghrelin (AG) and in an altered acylated ghrelin:unacylated ghrelin (AG:UAG)
ratio which may contribute to decreased oxidative stress and improved insulin sensitivity.
PROTOCOL I
Inclusion Criteria:
- Age 18-65 years
- BMI ≥ 35 kg/m^2
- Scheduled for bariatric surgery
- Considering bariatric surgery
- Waiting for insurance approval for bariatric surgery
- Currently not considering bariatric surgery, but otherwise eligible
- Enrollment in medical weight loss program
Exclusion Criteria:
- Smoking >7 cigarettes per day
- Precious malabsorptive or restrictive intestinal surgery
- Pregnant or breastfeeding
- Recent history of neoplasia (5
- Malabsorptive syndromes
- Inflammatory intestinal disease
- Established organ disfunction
- Allergy to acetaminophen
We found this trial at
1
site
1211 Medical Center Dr
Nashville, Tennessee 37232
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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