Treatment of Muscle Cramps in Patients With Liver Cirrhosis
| Status: | Completed |
|---|---|
| Conditions: | Other Indications, Gastrointestinal, Metabolic |
| Therapuetic Areas: | Gastroenterology, Pharmacology / Toxicology, Other |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 4/21/2016 |
| Start Date: | December 2011 |
| End Date: | April 2015 |
A Pilot Study of Hydroxychloroquine for the Treatment of Muscle Cramps in Patients With Cirrhosis
This is a pilot study to see if hydroxychloroquine (HCQ) if safe and effective to use with
patients having cramps due to their cirrhotic liver disease.
patients having cramps due to their cirrhotic liver disease.
This project is proposed as a pilot study to gather preliminary data for a full-scale
randomized trial to assess the efficacy and safety of hydroxychloroquine (HCQ) in the
treatment of muscle cramps in patients with cirrhosis.
randomized trial to assess the efficacy and safety of hydroxychloroquine (HCQ) in the
treatment of muscle cramps in patients with cirrhosis.
Inclusion Criteria:
- previous diagnosis of cirrhosis
- adult (>21 years)
- able to complete a written questionnaire in English
- stable and ambulatory
- MELD score < 25, Platelet count >25,000
Exclusion Criteria:
- people allergic to hydroxychloroquine, 4-aminoquinolone derivatives or any component
of the formulation
- previous diagnosis of retinal or visual field changes attributable to
4-aminoquinolone
- previous diagnosis of porphyria
- previous diagnosis of psoriasis
- fulminant hepatic failure
- pregnant women
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