Imaging Biomarkers of Delayed Sequelae in Trauma Brain Injury
| Status: | Completed |
|---|---|
| Conditions: | Parkinsons Disease, Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 100 |
| Updated: | 4/21/2016 |
| Start Date: | March 2012 |
| End Date: | December 2015 |
Imaging Biomarkers of Delayed Sequelae in Mild to Moderate Traumatic Brain Injury
The purpose of this study is to learn if a new brain imaging technology called DaTscan can
detect subtle changes in the brain that are similar to those seen in early Parkinson's
disease (PD). The results of this study may provide more information about a possible
association between mild to moderate traumatic brain injury (mTBI) and PD. The objectives of
this study are to define and describe a group of approximately 7,122 mTBI subjects and 7,122
subjects without mTBI (mTBI-) seen in the Emergency Rooms of NorthShore University
HealthSystem during the years 2006-2011, and to select from willing eligible subjects a
random sample of 100 mTBI subjects and 100 mTBI- subjects (of the same age and gender) to
undergo written informed consent, neurological examinations, blood drawing for DNA
extraction and storage, and DaTscan brain imaging. The investigators will compare the
findings from persons who experienced mTBI (cases) to persons without a history of brain
injury (mTBI- or "controls").
detect subtle changes in the brain that are similar to those seen in early Parkinson's
disease (PD). The results of this study may provide more information about a possible
association between mild to moderate traumatic brain injury (mTBI) and PD. The objectives of
this study are to define and describe a group of approximately 7,122 mTBI subjects and 7,122
subjects without mTBI (mTBI-) seen in the Emergency Rooms of NorthShore University
HealthSystem during the years 2006-2011, and to select from willing eligible subjects a
random sample of 100 mTBI subjects and 100 mTBI- subjects (of the same age and gender) to
undergo written informed consent, neurological examinations, blood drawing for DNA
extraction and storage, and DaTscan brain imaging. The investigators will compare the
findings from persons who experienced mTBI (cases) to persons without a history of brain
injury (mTBI- or "controls").
This study is being done to learn if a new brain imaging technology called DaTscan can
detect subtle changes in the brain ("biomarkers") that are similar to those seen in early
Parkinson's disease (PD). The results of this study may provide more information about a
potential link between mild to moderate traumatic brain injury (mTBI) and PD. We will
compare findings from persons who experienced mTBI ("cases") to persons without history of
brain injury (mTBI-or "controls"). This study may provide preliminary data that might be
used to help design future long-term studies.
The investigators propose scientific studies with one specific aim and two hypotheses:
Specific aim: to determine if one year post emergency room (ER) visits, DaTscan uptake
(Ioflupane I123 injection and single photon emission computerized tomography) is lower in
subjects exposed to mTBI (defined as a closed head trauma that results in loss of
consciousness or amnesia for less than 24 hours) than in subjects not exposed to mTBI
(without closed head trauma; mTBI-).
Hypotheses:
Hypothesis #1: mTBI is a risk factor for Parkinson's disease (PD). Hypothesis #2: DaTscan is
able to detect subclinical PD (as measured by a dopamine transporter deficiency) in mTBI
subjects.
detect subtle changes in the brain ("biomarkers") that are similar to those seen in early
Parkinson's disease (PD). The results of this study may provide more information about a
potential link between mild to moderate traumatic brain injury (mTBI) and PD. We will
compare findings from persons who experienced mTBI ("cases") to persons without history of
brain injury (mTBI-or "controls"). This study may provide preliminary data that might be
used to help design future long-term studies.
The investigators propose scientific studies with one specific aim and two hypotheses:
Specific aim: to determine if one year post emergency room (ER) visits, DaTscan uptake
(Ioflupane I123 injection and single photon emission computerized tomography) is lower in
subjects exposed to mTBI (defined as a closed head trauma that results in loss of
consciousness or amnesia for less than 24 hours) than in subjects not exposed to mTBI
(without closed head trauma; mTBI-).
Hypotheses:
Hypothesis #1: mTBI is a risk factor for Parkinson's disease (PD). Hypothesis #2: DaTscan is
able to detect subclinical PD (as measured by a dopamine transporter deficiency) in mTBI
subjects.
Inclusion Criteria:
- mTBI or mTBI- survey respondents
- Ages 18-100 years
- Without a history of parkinsonism or tremor
Exclusion Criteria:
- History of parkinsonism or tremor
- Lugol or iodide allergy
- Contraindicated medications for DaTscan
- Pregnancy or nursing mothers
- Renal or liver impairment
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