Gut Flora Dependent Metabolism of Dietary Phosphatidylcholine and Cardiovascular Disease
| Status: | Completed |
|---|---|
| Conditions: | Food Studies, Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Pharmacology / Toxicology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | April 2010 |
| End Date: | October 2014 |
The purpose of this study is to see if intestinal bacteria plays a role in choline
metabolism (a form of choline monitored in this study is called phosphatidylcholine, also
known as lecithin). This study will help to determine if choline metabolism is affected by
short-term antibiotic therapy, and/or can be altered by probiotic therapy (e.g. in the form
of eating yogurt).
metabolism (a form of choline monitored in this study is called phosphatidylcholine, also
known as lecithin). This study will help to determine if choline metabolism is affected by
short-term antibiotic therapy, and/or can be altered by probiotic therapy (e.g. in the form
of eating yogurt).
The purpose of this study is to see if intestinal bacteria plays a role in choline
metabolism (a form of choline monitored in this study is called phosphatidylcholine, also
known as lecithin). This study will help to determine if choline metabolism is affected by
short-term antibiotic therapy, and/or can be altered by probiotic therapy (e.g. in the form
of eating yogurt).
Metabolism is a process that turns foods we eat into fuel for our bodies. Choline is
nutrient found in a type of fat commonly found in foods. There is evidence that choline
metabolism by bacteria in the intestines may be linked to cardiac risk.
The purpose of this study is to see if intestinal bacteria plays a role in choline
metabolism (a form of choline monitored in this study is called phosphatidylcholine, also
known as lecithin). This study will help to determine if choline metabolism is affected by
short-term antibiotic therapy, and/or can be altered by probiotic therapy (e.g. in the form
of eating yogurt).
This single center study will randomize 30 normal, healthy volunteers to 1 of 3 groups:
Group 1: antibiotics for 1 week, followed by probiotics for 3 weeks; Group 2: antibiotics
for 1 week, followed by no probiotics for 3 weeks. Group 3: no antibiotics for 1 week,
followed by probiotics for 3 weeks.
The antibiotics to be used will be metronidazole (500 mg twice daily) and ciprofloxacin (500
mg daily) for one week. The probiotics to be used will be one serving size of standard
flavored yogurt (approximately 170 g) twice daily for up to three weeks.
Study visits will occur at baseline, 1 week, and 4 weeks. Blood and urine samples will be
collected at the start of each visit. Subjects will then eat 2 hard boiled eggs and be given
a standard medical isotope. Additional blood samples will be obtained at 1, 2, 3, 4, and 6
hours, and a urine sample will be collected at 6 hours. Samples will be analyzed for choline
levels, its byproducts, and isotope levels.
metabolism (a form of choline monitored in this study is called phosphatidylcholine, also
known as lecithin). This study will help to determine if choline metabolism is affected by
short-term antibiotic therapy, and/or can be altered by probiotic therapy (e.g. in the form
of eating yogurt).
Metabolism is a process that turns foods we eat into fuel for our bodies. Choline is
nutrient found in a type of fat commonly found in foods. There is evidence that choline
metabolism by bacteria in the intestines may be linked to cardiac risk.
The purpose of this study is to see if intestinal bacteria plays a role in choline
metabolism (a form of choline monitored in this study is called phosphatidylcholine, also
known as lecithin). This study will help to determine if choline metabolism is affected by
short-term antibiotic therapy, and/or can be altered by probiotic therapy (e.g. in the form
of eating yogurt).
This single center study will randomize 30 normal, healthy volunteers to 1 of 3 groups:
Group 1: antibiotics for 1 week, followed by probiotics for 3 weeks; Group 2: antibiotics
for 1 week, followed by no probiotics for 3 weeks. Group 3: no antibiotics for 1 week,
followed by probiotics for 3 weeks.
The antibiotics to be used will be metronidazole (500 mg twice daily) and ciprofloxacin (500
mg daily) for one week. The probiotics to be used will be one serving size of standard
flavored yogurt (approximately 170 g) twice daily for up to three weeks.
Study visits will occur at baseline, 1 week, and 4 weeks. Blood and urine samples will be
collected at the start of each visit. Subjects will then eat 2 hard boiled eggs and be given
a standard medical isotope. Additional blood samples will be obtained at 1, 2, 3, 4, and 6
hours, and a urine sample will be collected at 6 hours. Samples will be analyzed for choline
levels, its byproducts, and isotope levels.
Inclusion Criteria:
- Men and women age 18 years or above.
- Able to provide informed consent and comply with study protocol
Exclusion Criteria:
- Significant chronic illness or end-organ dysfunction, including known history of
heart failure, renal failure, pulmonary disease, or hematologic diseases.
- Active infection or received antibiotics within 2 months of study enrollment
- Use of OTC probiotic within past 2 months, or ingestion of yogurt within past month
- Chronic gastrointestinal disorders, or intolerance to probiotic therapy
- Allergies to eggs.
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