Pharmacokinetic, Safety and Tolerability Study of Aclidinium/Formoterol Fixed Dose Combination and Formoterol in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Inclusion Criteria:

- Current or former cigarette smokers with a cigarette smoking history of at least 10
pack-years

- A diagnosis of stable moderate to severe COPD and stable airway obstruction as
defined by the Global Initiative for Chronic Obstructive Lung Disease guidelines and
stable airway obstruction.

Exclusion Criteria:

- Patients who have been hospitalized for an acute COPD exacerbation within three
months prior to Screening

- Any respiratory tract infection (including the upper respiratory tract) or COPD
exacerbation in the six weeks before Screening

- Patients with any clinically significant respiratory conditions other than COPD

- Clinical history that suggests that the patient has asthma as opposed to COPD

- Chronic use of oxygen therapy ≥ 15 hours/day

- Patients with clinically significant cardiovascular conditions

- Patients with a history of hypersensitivity reaction to inhaled anticholinergics,
beta-2 agonists, sympathomimetic amines, or inhaled medications