Efficacy of Dietary Sodium Restriction of Improving Vascular Endothelial Function in Middle Aged and Older Adults
| Status: | Completed |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 50 - 79 |
| Updated: | 4/21/2016 |
| Start Date: | February 2009 |
| End Date: | January 2012 |
The investigators hypothesize that reducing salt in the diet will improve the function of
blood vessels in middle aged and older adults with moderately elevated systolic blood
pressure, by increasing the amount of BH4 and nitric oxide in your blood vessels and
reducing the amount of oxidative stress.
blood vessels in middle aged and older adults with moderately elevated systolic blood
pressure, by increasing the amount of BH4 and nitric oxide in your blood vessels and
reducing the amount of oxidative stress.
The improvement in blood vessel function will be determined over a 10 week period. Subjects
will be randomly assigned to either a 'low salt' condition (placebo pills + 1200 mg dietary
sodium) or a 'normal salt' condition (2300 mg sodium chloride pills + 1200 mg dietary
sodium) and monitored for 5 weeks. After the initial set of 5 weeks, the subjects are
switched into the opposite condition, completing the cross-over study design. During weeks
1-4 and 6-9, subjects are monitored weekly with 24 hour urine collections and diet logs. The
assessment of the primary outcome (blood vessel function) is completed during weeks 5 and
10. BH4 and ascorbic acid are also administered during weeks 5 and 10 to measure the effects
of sodium intake on endogenous BH4 levels and vascular oxidative stress.
will be randomly assigned to either a 'low salt' condition (placebo pills + 1200 mg dietary
sodium) or a 'normal salt' condition (2300 mg sodium chloride pills + 1200 mg dietary
sodium) and monitored for 5 weeks. After the initial set of 5 weeks, the subjects are
switched into the opposite condition, completing the cross-over study design. During weeks
1-4 and 6-9, subjects are monitored weekly with 24 hour urine collections and diet logs. The
assessment of the primary outcome (blood vessel function) is completed during weeks 5 and
10. BH4 and ascorbic acid are also administered during weeks 5 and 10 to measure the effects
of sodium intake on endogenous BH4 levels and vascular oxidative stress.
Inclusion Criteria:
- 50-79 years of age
- SBP 130-159 mmHg
Exclusion Criteria:
- Have been sick with an infection in the past two weeks
- Are currently sick or have ongoing health problems such as kidney or CVD
- Have lost more than 11 lbs. in the last 3 months
- Are taking any type of antioxidants
- Smoke or have alcohol problems
- Have blood glucose levels higher than 126 mg/dL
- Have resting SBP below or less than 100 mmHg or greater than 159 mmHg
- Have a resting diastolic blood pressure greater than 99 mmHg
- Have a BMI greater than 40 kg/m^2
- Are presently consuming less than 9 or greater than 18 grams of salt / day
- Have a baseline FMD of greater than 6%
- Are taking any of the following types of drugs: blood thinners, anti-seizure
medications, ant-inflammatory drugs
- Participate in any high endurance athletic training
- Taking Hormone Replacement Therapy
- Have not been post-menopausal for at least 1 year
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