Psychosis: Early Detection, Intervention and Prevention
| Status: | Completed |
|---|---|
| Conditions: | Schizophrenia, Major Depression Disorder (MDD), Psychiatric, Psychiatric, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 12 - 35 |
| Updated: | 4/21/2016 |
| Start Date: | May 2003 |
| End Date: | December 2014 |
The primary aim of this application is to conduct a randomized, controlled clinical trial of
a specialized mental health service delivery system specifically developed for prodromal
psychotic disorders. The intervention is Family-aided Assertive Community Treatment (FACT).
The goal of the treatment is prevention of psychosis and disability. This study will assess
experimentally the clinical effectiveness of this new type of mental health service. Other
domains of outcome include cognitive dysfunction and functional disability.
a specialized mental health service delivery system specifically developed for prodromal
psychotic disorders. The intervention is Family-aided Assertive Community Treatment (FACT).
The goal of the treatment is prevention of psychosis and disability. This study will assess
experimentally the clinical effectiveness of this new type of mental health service. Other
domains of outcome include cognitive dysfunction and functional disability.
The proposed study will be part of a larger program, Portland Identification and Early
Referral (PIER), under foundation, NIH and Center for Mental Health Services sponsorship,
that has established a population-based system of early detection for Greater Portland,
Maine. Previous and present effort has educated and trained the community-at-large and all
health, education and other professionals, with the result that referrals are occurring at
the expected frequency. The principal strategy is to intervene early, prior to onset, in the
course of the onset of psychotic disorders to arrest the development of psychotic symptoms
and functional disability. The test treatment is a specialized combination of
psychoeducational multifamily group and assertive community treatment.
The project will support a team of clinical staff with the ability to: a. foster detection
of prodromal disorders in the Greater Portland community by general practitioners, guidance
counselors, mental health professionals and the general public; b. accurately assess
individuals at high risk for psychosis; c. reliably deliver an evidence-based psychosocial
and, if indicated, pharmacological treatment package using standardized methodology. The
research study will test, in a randomized controlled trial, the symptomatic and functional
outcome of treatment in 100 subjects ages 12 to 35 identified by that system. It will allow
the analysis of key social factors contributing to psychosis and their interaction with the
treatment conditions and each other.
Referral (PIER), under foundation, NIH and Center for Mental Health Services sponsorship,
that has established a population-based system of early detection for Greater Portland,
Maine. Previous and present effort has educated and trained the community-at-large and all
health, education and other professionals, with the result that referrals are occurring at
the expected frequency. The principal strategy is to intervene early, prior to onset, in the
course of the onset of psychotic disorders to arrest the development of psychotic symptoms
and functional disability. The test treatment is a specialized combination of
psychoeducational multifamily group and assertive community treatment.
The project will support a team of clinical staff with the ability to: a. foster detection
of prodromal disorders in the Greater Portland community by general practitioners, guidance
counselors, mental health professionals and the general public; b. accurately assess
individuals at high risk for psychosis; c. reliably deliver an evidence-based psychosocial
and, if indicated, pharmacological treatment package using standardized methodology. The
research study will test, in a randomized controlled trial, the symptomatic and functional
outcome of treatment in 100 subjects ages 12 to 35 identified by that system. It will allow
the analysis of key social factors contributing to psychosis and their interaction with the
treatment conditions and each other.
Inclusion Criteria:
- Prodromal psychotic symptoms
- Age 12-35
- In catchment area (greater Portland, Maine)
Exclusion Criteria:
- Previous or current psychotic episode
- IQ less than 70
- Outside catchment area
- Toxic psychosis
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