A Study of AGS-1C4D4 in Pancreatic Cancer Subjects Previously Treated in Protocol 2008002

Subjects will receive a maintenance dose of AGS-1C4D4 every 3 weeks (Q3W) in addition to the
gemcitabine administration. If subjects have grade 4 adverse events considered to be related
to AGS-1C4D4 at anytime during the study, AGS-1C4D4 treatment will be discontinued for that
subject.

Subjects will continue to have their tumor status assessed by computerized tomography (CT)
and magnetic resonance (MRI) scans according to Response Evaluation Criteria in Solid Tumors
(RECIST Version 1.1) guidelines every eight weeks (Q8W). Subjects without evidence of
disease progression will continue to receive AGS-1C4D4 and gemcitabine until intolerability,
disease progression or consent withdrawal.

Subjects who discontinue AGS-1C4D4 for any reason will undergo an end of study visit 4 weeks
after their last AGS-1C4D4 infusion.

Inclusion Criteria:

- Subject has stable disease or better per Response Evaluation Criteria in Solid Tumors
(RECIST) criteria v.1.1. in Protocol 2008002

Exclusion Criteria:

- More than 6 weeks (2 doses) has lapsed from the time of the last infusion in
AGS-1C4D4 Protocol 2008002

- Use of the following prohibited medications / therapies:

- Monoclonal antibody therapy, other than AGS-1C4D4

- Chemotherapy, other than gemcitabine

- Investigational therapy other than AGS-1C4D4

- Erlotinib (Tarceva)

- Any clinical condition which would not allow safe conduct of this study