Effectiveness Registry to Study Therapies for Arthritis and Inflammatory Conditions: The Corrona CERTAIN Sub-study

Biologic therapies (including biologic medications like Enbrel, Humira, Remicade, Cimzia,
Simponi, Actemra, Rituxan and Orencia) have changed the treatment of RA, but the differences
in safety and/or effectiveness of each biologic therapy are not all known. We are doing this
study in order to try to see if one or more of these treatments are better than the others.
The use of databases like the CORRONA Organization database gives us information that helps
us to understand why such drugs are used, reasons for starting or stopping drugs, for whom
they are prescribed, and to monitor changes in patients' abilities to perform daily
activities and gather information on family or social history.

Inclusion Criteria:

- The CORRONA CERTAIN Sub-study is particularly focused on understanding the
effectiveness and safety of biologic medications. Male and female patients, who

1. are at least 18 years of age;

2. have a documented diagnosis of RA by their treating rheumatologist;

3. have at least moderate disease activity; and

4. are initiating a biologic agent that has not be used for their treatment in the
past are eligible to participate.

Moderate disease activity is defined by a CDAI score greater than 10.

Exclusion Criteria:

Disease other than RA that do not meet the inclusion criteria