Exploring Behavioral Interventions to Improve Heart Failure
| Status: | Completed |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | August 2010 |
| End Date: | August 2015 |
Exploring Tai Chi as a Behavioral Intervention for Heart Failure Patients
The objective of this research is to compare Tai Chi versus Resistance Exercise, Health
Education and usual care for changes in cardiac functional capacity measured for ability of
the heart to pump by measuring ejection fraction (EF), end systolic and diastolic volumes in
heart failure (HF) patients. Also measured will be changes in physical function measured by
walking speed and distance in the 6-min walk task, work performed during a bicycle task, and
changes in daily physical activity. The investigators will compare groups for altered
well-being including: depression, sleep disturbances, fatigue, mindfulness, spirituality and
quality of life. In addition the investigators will compare groups for altered vascular and
pro-inflammatory markers, catecholamines, and autonomic function at rest and in response to
the bicycle task. Also, the investigators will assess cardiac related hospitalization and
death over a 12 month period by examining medical records.
Education and usual care for changes in cardiac functional capacity measured for ability of
the heart to pump by measuring ejection fraction (EF), end systolic and diastolic volumes in
heart failure (HF) patients. Also measured will be changes in physical function measured by
walking speed and distance in the 6-min walk task, work performed during a bicycle task, and
changes in daily physical activity. The investigators will compare groups for altered
well-being including: depression, sleep disturbances, fatigue, mindfulness, spirituality and
quality of life. In addition the investigators will compare groups for altered vascular and
pro-inflammatory markers, catecholamines, and autonomic function at rest and in response to
the bicycle task. Also, the investigators will assess cardiac related hospitalization and
death over a 12 month period by examining medical records.
Inclusion Criteria:
1. Ability to perform a 6-minute walk task, with or without use of a cane or walker
(must use the same walking assistance device during each session), and walk under 500
meters during task.
2. Symptoms of chronic heart failure for at least 3 months.
3. Clinically stable- defined as not having been hospitalized for a 3 month period, on
stable doses of neurohormonal blocking agents and diuretics for at least 3 months.
4. ACC/AHA stages B and C
5. Ability to perform light to moderate exercise (NYHA functional class II and III)
6. Presence of HF with an ejection fraction less than 40%, or diastolic dysfunction
7. Ability to give informed consent
8. At least18 years of age
Exclusion Criteria:
1. History of recent myocardial infarction (1 month)
2. Angina not adequately managed with nitrates.
3. Aortic or mitral stenosis
4. Coronary revascularization, mitral valve repair or any other cardiac surgery or
implantation of a biventricular pacemaker within the past 6 months.
5. Severe COPD
6. Recent stroke or significant cerebral neurologic impairment.
7. Active Suicidality
8. Currently participating in an exercise program.
9. Currently taking mood stabilizers (e.g. lithium), benzodiazepines or antipsychotics.
10. Medications (steroids) and medical conditions affecting immune status not limited to
Grave's Disease, Rheumatoid Arthritis, Hashimoto's Disease, Sjogren's Disease, Lupus,
Multiple Sclerosis
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