Retrospective Analysis of Outcomes With a Pharmacogenomic Algorithm
| Status: | Completed |
|---|---|
| Conditions: | Anxiety, Anxiety, Depression |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | January 2011 |
| End Date: | September 2011 |
A Retrospective Analysis of Outcomes in Outpatients With Major Depressive Disorder (MDD) in a Staff Model HMO: Pharmacogenetic Algorithm for Psychotropic Pharmacotherapeutic Applications
Antidepressants are among the most widely prescribed medications, yet only 35-45% of
patients achieve remission following an initial antidepressant trial. The financial burden
of treatment failures in direct treatment costs, disability, decreased productivity, and
missed work may in part derive from a mismatch between optimal, and actual, medications
prescribed. The present one year retrospective study seeks to evaluate the indirect and
direct healthcare costs for 96 patients with a DSM-IV-TR depressive or anxiety disorder, in
relation to an interpretive reporting system designed to predict antidepressant responses
based on DNA variations in cytochrome P450 genes (CYP2D6, CYP2C19, CYP1A2), the serotonin
transporter gene (SLC6A4), and the serotonin 2A receptor (5HTR2A) genes.
patients achieve remission following an initial antidepressant trial. The financial burden
of treatment failures in direct treatment costs, disability, decreased productivity, and
missed work may in part derive from a mismatch between optimal, and actual, medications
prescribed. The present one year retrospective study seeks to evaluate the indirect and
direct healthcare costs for 96 patients with a DSM-IV-TR depressive or anxiety disorder, in
relation to an interpretive reporting system designed to predict antidepressant responses
based on DNA variations in cytochrome P450 genes (CYP2D6, CYP2C19, CYP1A2), the serotonin
transporter gene (SLC6A4), and the serotonin 2A receptor (5HTR2A) genes.
Inclusion Criteria:
- Major Depressive Disorder
- Dysthymic Disorder
- Depressive Disorder NOS
- Obsessive Compulsive Disorder (OCD)
- Generalized Anxiety Disorder
- Panic Disorder
- Anxiety Disorder NOS
- Post-Traumatic Stress Disorder (PTSD)
- Social Phobia
Exclusion Criteria:
- Bipolar Disorder
- Schizophrenia
- Schizoaffective Disorder
- Previous pharmacogenomic testing
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