Drug Interaction Study of Multiple Doses of Isavuconazole and a Single Dose of Bupropion

Inclusion Criteria:

- The subject has a body weight of at least 45 kg and a body mass index of 18 to 32
kg/m2, inclusive

- The subject's clinical laboratory test results at Screening and Day 1 are within
normal limits unless the Investigator considers the abnormality to be "not clinically
significant." Results for aspartate aminotransferase (AST), alanine aminotransferase
(ALT), and total bilirubin must not be above the normal range

- Subject agrees to sexual abstinence, or is surgically sterile, or is using a
medically acceptable double barrier method to prevent pregnancy during the study and
for three weeks after the follow up phone call at the end of the study, or, if
female, is postmenopausal

Exclusion Criteria:

- The subject has a history of unexplained syncope, cardiac arrest, unexplained cardiac
arrhythmia or torsade de pointes, structural heart disease, or family history of Long
QT syndrome (suggested by sudden death of a close relative at a young age due to
possible or probable cardiac causes)

- The subject has/had a symptomatic, viral, bacterial (including upper respiratory
infection), or fungal (non-cutaneous) infection within 1 week prior to clinic
admission on Day -1

- The subject has a positive result for hepatitis B surface antigen or hepatitis C
antibodies at Screening or is known to be positive for human immunodeficiency virus

- The subject has a known or suspected allergy to any of the components of the trial
products or the azole class of compounds, or a history of multiple and/or severe
allergies to drugs or foods (as judged by the Investigator), or a history of severe
anaphylactic reactions

- The subject is a smoker (any use of tobacco or nicotine containing products) in the
last 6 months

- The subject has had treatment with prescription drugs or complementary and
alternative medicines within 14 days prior to Day -1, or over-the-counter medication
within 1 week prior to Day -1, with the exception of acetaminophen up to 2 g/day

- The subject has received an experimental agent within 30 days or 5 half-lives,
whichever is longer, prior to Day -1

- The subject has a history of suicidal behavior and/or ongoing suicidal ideation as
assessed using C-SSRS (Columbia - Suicide Severity Rating Scale) at Screening or at
Clinic Check-In (any response of "yes" to the Suicidal Ideation questions on the
C-SSRS)

- The subject has a current or past history of seizure disorder or epilepsy

- The subject has a current or past history of depression, anorexia nervosa or bulimia