Chest Imaging, Breath, and Biomarkers in a Screening Trial
| Status: | Completed |
|---|---|
| Conditions: | Lung Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 40 - 75 |
| Updated: | 5/19/2017 |
| Start Date: | September 2008 |
| End Date: | May 2014 |
A Clinical Trial to Develop Chest Imaging, Breath, and Biomarkers in a Screening Trial
The investigators would like to see if lung cancer screening with chest x-rays,computer
aided detection (CAD)and a lose dose CT scan can detect lung cancer in early stages when it
is more responsive to treatment. The investigators would also like to see if early detection
will reduce the incidence of symptomatic advanced lung cancer compared to no screening in
former and current smokers with or without a family history of lung cancer who are 40-75
years old.
aided detection (CAD)and a lose dose CT scan can detect lung cancer in early stages when it
is more responsive to treatment. The investigators would also like to see if early detection
will reduce the incidence of symptomatic advanced lung cancer compared to no screening in
former and current smokers with or without a family history of lung cancer who are 40-75
years old.
The fight against lung cancer is waged on three major fronts: prevention, detection and
treatment. Our goal is to determine if chest x-rays,computer aided detection (CAD)and a CT
scan can detect disease earlier when treatment is more effective. If we improve the
detection of disease, we will see if screening reduces the incidence of symptomatic advanced
lung cancer relative to no screening in people at high risk to develop lung cancer.
treatment. Our goal is to determine if chest x-rays,computer aided detection (CAD)and a CT
scan can detect disease earlier when treatment is more effective. If we improve the
detection of disease, we will see if screening reduces the incidence of symptomatic advanced
lung cancer relative to no screening in people at high risk to develop lung cancer.
Inclusion Criteria:
- ages 40-75 years
- If ages 40-59, then one of the following criteria needs to be met:
- Current or ex-smoker with >25 pack years and a family history of lung
cancer(parent or sibling) OR
- current or ex-smoker with > 25 pack years and COPD OR
- current or ex-smoker with a > 35 pack year history
- If ages 60-75, then one of the following additional criteria needs to be met:
- Current or ex-smoker with >25 pack years and a family history of lung cancer
(parent or sibling) OR
- Current or ex-smoker with >25 pack years and COPD OR
- Current or ex-smoker with a >30 pack year history
- Subject is able to return to Cleveland Clinic for annual follow-up screening
- Subject is willing to sign a medical release form
Exclusion Criteria:
- Current health requires oxygen
- Have had a chest x-ray or CT of the chest within the last 6 months
- Previous pneumonectomy
- Lobectomy of the lung within the last 5 years
- Diagnosed malignancy within the last 5 years, excluding non-melanoma skin cancer,
carcinoma in situ of the cervix and localized prostate cancer
- A medical condition that would prevent treatment for lung cancer
- Within the last 6 weeks, one of the following has occured:
- A new cough or chronic cough that has gotten worse
- Either new shortness of breath, or any worsening of shortness of breath
- A cough producing blood
- Constant chest pain
- Respiratory infection, pneumonia, or cold
- Unintentional and unexplained weight loss greater than 5% of total body weight
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