A Safety Study Assessing the Effects of Receiving Genome Sequencing Results
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 8/4/2018 |
| Start Date: | September 2012 |
| End Date: | August 2018 |
Personal Genomics: A Safety Study Assessing the Effects of Receiving Genome Sequencing Results
This study uses new methods called "genome sequencing" that allow the investigators to study
part or all of a person's genome. The genome is the collection of all of a person's genes.
Genes carry the instructions that our bodies need to develop and function. Genes are passed
on from one generation to the next. Genome sequencing can study all of a person's genome
(whole genome sequencing) or just parts of their genome (whole exome sequencing). In the
study, the investigators refer to all these research methods as 'genome sequencing'. Genome
sequencing typically shows a large number of gene changes, known as "variants." Some (but not
all) of these genetic variants may be linked to increased risks of diseases other than
cancer.
The purpose of this study is to learn what kinds of genetic variants the patient wants to
learn about from their genome.
part or all of a person's genome. The genome is the collection of all of a person's genes.
Genes carry the instructions that our bodies need to develop and function. Genes are passed
on from one generation to the next. Genome sequencing can study all of a person's genome
(whole genome sequencing) or just parts of their genome (whole exome sequencing). In the
study, the investigators refer to all these research methods as 'genome sequencing'. Genome
sequencing typically shows a large number of gene changes, known as "variants." Some (but not
all) of these genetic variants may be linked to increased risks of diseases other than
cancer.
The purpose of this study is to learn what kinds of genetic variants the patient wants to
learn about from their genome.
Inclusion Criteria:
Cancer survivors (sample #1):
- Consented individuals with a personal history of cancer enrolled on protocols 09-068
or 96-051 who have indicated their interest in participating in future research or
learning their results, defined as either:
- For samples #1-2: checking "yes" to the re-contact question in their consent form; or,
- checking "I wish to know these results" in their consent form.
Unaffected Relatives (sample #2):
- Consented individuals with no personal history of cancer enrolled on protocols 09-068
and 96-051 (parents or siblings of probands) who have indicated their interest in
participating in future research or learning their results, defined as either:
- checking "yes" to the re-contact question in their consent form or,
- checking "I wish to know these results" in their consent form
Focus group participants (sample #3- hypothetical group):
- Individuals with or without a personal history of cancer
Exclusion Criteria:
- Non-English speakers; or,
- Individuals < 18 years of age; or
- Individuals unable to complete the follow-up assessments (e.g., unavailable to
complete questionnaires over the 12-month study period).
- For samples #1-2: Individuals who indicate in their consent form that they do not want
to
- checking "no" to the re-contact question in their consent form; or,
- checking "I prefer not to know these results" in their consent form
- Cases where it is unclear whether individuals' are interested in participating in
future research or learning their results, defined as:
- Not answering the re-contact question in their consent form (i.e., left blank); or,
- Not answering the re-contact question because it did not exist in the version of the
consent form that was originally signed (i.e., re-contact question missing).
We found this trial at
1
site
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
Click here to add this to my saved trials
