Vapocoolant (Pain Ease) Use for Venipuncture

This is a prospective, randomized, blinded, comparator study. This study design is
considered standard for establishing safety and efficacy data. Active treatment vapocoolant
spray (Pain Ease Medium Stream) spray) will be used. There will be a placebo (sterile water)
in this study. The population selected for this study, adults (excluding the very old, > 80
years old) represents a patient population that may benefit from vapocoolant spray. This is
a patient population that according to the treating health care provider already requires
venipuncture for "blood draw" but not intravenous cannulation. Because venipuncture is a
painful procedure, vapocoolant may confer benefit for the relief of pain.

Inclusion Criteria:

- Patient needing venipuncture ("blood draw') but not intravenous cannulation

- Adult 18 years and older up to and and including 80 years old

- Stable patient

- Mentally competent patient able to understand the consent form

Exclusion Criteria:

- Patients with any allergies to the spray components (e.g. 1,1,1,3,3
pentafluoropropane or 1,1,1,2, tetrafluoroethane )

- Critically ill or unstable (e.g. sepsis or shock)

- Extremes of age: geriatric (> 80 years) or pediatric ( < 18 years old)

- Pregnant

- Venipuncture site located in area of compromised blood supply. Examples include :
patients with peripheral vascular disease, gangrene, Raynaud's disease, Buerger's
disease.

- Venipuncture site located in area of insensitive skin; patients with a peripheral
neuropathy including diabetic neuropathy.

- Patient intolerant of cold or with hypersensitivity to the cold.

- Patient unable or unwilling to give consent.

- Prior experience with vapocoolant spray

- Currently in another research trial