Impact of Black Pepper on Energy Expenditure and Substrate Utilization
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 50 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | April 2011 |
| End Date: | July 2011 |
A Randomized, Cross-Over Trial to Evaluate the Acute Effects of Black Pepper on Energy Expenditure and Fat Oxidation in Humans
As obesity rates worldwide continue to increase, there is a focus on identifying active food
ingredients which increase metabolic rate which can be used as a dietary supplement in the
treatment of overweight and obesity. Promising animal and cell studies have suggested a role
for black pepper and an active component of black pepper, piperine, in energy expenditure.
However, the effects of black pepper have not been determined in humans. The investigators
hypothesis if that consumption of 1.5g black pepper (0.5g in each of three meals over one
day) will result in an elevation in 24-h resting energy expenditure when contrasted to a
control day (no black pepper, same diet intake).
ingredients which increase metabolic rate which can be used as a dietary supplement in the
treatment of overweight and obesity. Promising animal and cell studies have suggested a role
for black pepper and an active component of black pepper, piperine, in energy expenditure.
However, the effects of black pepper have not been determined in humans. The investigators
hypothesis if that consumption of 1.5g black pepper (0.5g in each of three meals over one
day) will result in an elevation in 24-h resting energy expenditure when contrasted to a
control day (no black pepper, same diet intake).
Inclusion Criteria:
- Woman
- Postmenopausal
- Aged 50-65 years
- BMI 25-35kg/m2
- Not taking blood pressure or anti-inflammatory medications or any other medications
that may impact the results
- Thyroid hormone profile within the normal reference range
- No medical condition which may impact the results (e.g. diabetes)
- Accustomed to eating regular meals including breakfast
Exclusion Criteria:
- Smoker
- Heavy exerciser (defined as >150 minutes/week for more than 3 months)
- Abuses alcohol or drugs
- Vegetarian
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