Arterial Elasticity: A Substudy of Strategic Timing of AntiRetroviral Treatment (START)
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, HIV / AIDS |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | November 2009 |
| End Date: | September 2015 |
The purpose of this study is to find out if starting anti-retroviral therapy (ART) above 500
cluster-of-differentiation-4 (CD4)+ cells/milliliter (mL) ('early ART group') is better at
reducing the stiffness of arteries than waiting to start ART until the CD4+ drops below 350
cells/mL ('deferred ART group'). Artery stiffness has been associated with an increased risk
of cardiovascular (heart) disease, and could be useful as an earlier indicator of heart
disease. In this study, the stiffness of arteries will be measured at study entry, months 4,
8, 12, and annually thereafter, using a tonometer on the participant's forearm.
cluster-of-differentiation-4 (CD4)+ cells/milliliter (mL) ('early ART group') is better at
reducing the stiffness of arteries than waiting to start ART until the CD4+ drops below 350
cells/mL ('deferred ART group'). Artery stiffness has been associated with an increased risk
of cardiovascular (heart) disease, and could be useful as an earlier indicator of heart
disease. In this study, the stiffness of arteries will be measured at study entry, months 4,
8, 12, and annually thereafter, using a tonometer on the participant's forearm.
Inclusion Criteria:
- Simultaneous co-enrollment in the START study
- Signed informed consent
Exclusion Criteria:
- Inability to ascertain waveform measurements that can be analyzed, i.e. atrial
fibrillation
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