Characterization of LV Strain Patterns in Mildly Elevated PCWP and PAH.
| Status: | Completed |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), High Blood Pressure (Hypertension), Cardiology, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | February 2013 |
| End Date: | December 2014 |
Echo Study - Characterization of LV Strain Patterns in Patients With Mildly Elevated PCWP and Pulmonary Hypertension
The purpose of this study is to determine if patients with pulmonary hypertension and mildly
elevated heart pressure known as PCWP will exhibit different patterns on echocardiography
and that these patterns will predict treatment response to sildenafil, a drug given for this
condition.
elevated heart pressure known as PCWP will exhibit different patterns on echocardiography
and that these patterns will predict treatment response to sildenafil, a drug given for this
condition.
Inclusion Criteria:
- Patients with New York Heart Association/World Health
Organization(NYHA/WHO)functional class II-III
- Patients with mean pulmonary artery pressure >25 mmHg, pulmonary capillary wedge
pressure >15 mmHg ≤18, and pulmonary vascular resistance >3 wood units
- Age >18 and <80
- Stable on antihypertensives and diuretics>3 months
- No evidence of active ischemic heart disease
- 6 minute walk distance >150 meters and <450 meters
Exclusion Criteria:
- - Left ventricular ejection fraction <50%
- Patients with significant restrictive lung disease (FVC<60% predicted) and/or
significant obstructive lung disease (FEV1 <55% predicted) within 1 year of
enrollment
- Poorly interpretable grey scale echocardiographic images
- Contraindications to right heart catheterization
- Nitroglycerin therapy
- Moderate-severe aortic and mitral valve abnormality
- Contraindications to submaximal exercise testing
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