Proton Pump Inhibitor (PPI) Responsive Eosinophilic Esophagitis EoE: Gastroesophageal Reflux Disease (GERD) or Eosinophilic Esophagitis (EoE)?
| Status: | Completed |
|---|---|
| Conditions: | Gastroesophageal Reflux Disease |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/23/2017 |
| Start Date: | March 2013 |
| End Date: | March 2017 |
PPI Responsive Esophageal Eosinophilia: GERD or Eosinophilic Esophagitis?
The investigators would like to determine if there are patients with PPI responsive
Eosinophilic Esophagitis Infiltration that have significant loss of esophageal
distensibility suggestive of esophageal fibrosis typical of classic Eosniophilic
Esophagitis.
If this group of patients exists, the investigators would like to determine if they have the
typical endoscopic features of EoE rather than those of GERD.
Eosinophilic Esophagitis Infiltration that have significant loss of esophageal
distensibility suggestive of esophageal fibrosis typical of classic Eosniophilic
Esophagitis.
If this group of patients exists, the investigators would like to determine if they have the
typical endoscopic features of EoE rather than those of GERD.
Inclusion criteria:
- Age 18 or older
- Have either mild-to-moderate Los Angeles (LA) Classification System grade B,
moderately severe LA grade C, or severe LA grade D erosive reflux esophagitis
- Or patients having a clinically indicated pH/impedance monitoring on proton pump
inhibitor therapy for indications of gastroesophageal reflux disease.
Exclusion criteria:
- Neoplasm of the esophagus or stomach
- Inability to read due to: Blindness, cognitive dysfunction, or English language
illiteracy
- Disorders which predispose to unreliable responses such as Schizophrenia, Alzheimer's
disease or significant memory loss
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