Acute Renal Failure Post Liver Transplantation
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - 71 |
| Updated: | 4/21/2016 |
| Start Date: | July 2007 |
| End Date: | July 2014 |
Acute Renal Failure Post Liver Transplantation: The Role of Cytokines and Oxidative Stress
Trial to test the effect of administering N-acetylcysteine on cytokines and markers of
oxidant stress and the incidence of acute renal failure post liver tranplant
oxidant stress and the incidence of acute renal failure post liver tranplant
1. To determine levels of pro-inflammatory cytokines and oxidative stress markers in liver
transplant patients during post-transplant period
2. To correlate changes in pro-inflammatory cytokines and markers of oxidative stress to
acute renal failure and acute rejection
3. To determine the impact of using N-acetylcysteine on cytokines and markers of oxidative
stress and the incidence of acute renal failure post liver transplantation
transplant patients during post-transplant period
2. To correlate changes in pro-inflammatory cytokines and markers of oxidative stress to
acute renal failure and acute rejection
3. To determine the impact of using N-acetylcysteine on cytokines and markers of oxidative
stress and the incidence of acute renal failure post liver transplantation
Inclusion Criteria:
- First liver transplant
- Normal renal function before transplantation [serum creatinine ≤ 1.5 mg / dl]
- No requirements for dialysis before transplantation
- Age greater than 18 years
Exclusion Criteria:
- Re-transplant
- Renal dysfunction i.e. serum creatinine > 1.5 mg/dl
- Need for dialysis before transplantation
- Presence of Hepatorenal or Hepatopulmonary syndrome*
- Combined liver and kidney transplant
- Peptic ulcer disease
- Pregnancy
We found this trial at
1
site
Dallas, Texas 75246
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