Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy



Status:Active, not recruiting
Conditions:Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 100
Updated:8/19/2018
Start Date:December 2011
End Date:January 2021

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Trial Summary
Trial Overview
Inclusion Criteria

Study of Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy

Cardiac resynchronization therapy with pacemaker alone, or in combination with a
cardioverter-defibrillator, prolongs life and decreases risk of heart failure exacerbation in
patients with low ejection fraction and wide QRS. Some patients achieve decrease in QRS
duration 6 months after cardiac resynchronization therapy. Such phenomenon is called reverse
electrical remodeling of native conduction. Retrospective analysis showed that reverse
electrical remodeling of the native conduction after at least 6 months of CRT is associated
with decreased rate of ventricular arrhythmias and better survival. This study is designed to
study reverse electrical remodeling prospectively.


Inclusion Criteria:

- patients undergoing implantation of a CRT-D

Exclusion Criteria:

- age < 18 y

- pregnancy or planned pregnancy
We found this trial at
1
site
Johns Hopkins Hospital
1800 Orleans St.
Baltimore, Maryland 21287
410-955-5000
Johns Hopkins Hospital Patients are the focus of everything we do at The Johns Hopkins...
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Baltimore, MD
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