Effect of Meal Number, Frequency, and Form on Satiety and Metabolism After Weight Loss Surgery
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 21 - 60 |
| Updated: | 12/30/2016 |
| Start Date: | September 2010 |
| End Date: | July 2014 |
Analyze the effect of meal pattern (meal number, frequency, and form) on satiety, gut
peptides, insulin, and glucose levels in individuals before and 12-15 months after gastric
bypass surgery (GBP).
peptides, insulin, and glucose levels in individuals before and 12-15 months after gastric
bypass surgery (GBP).
The main goal is to study the effect of meal number, size and texture on metabolism and
incretin levels after GBP. Patients will be studied before GBP (T0) and 12-15 months after
GBP (T1). At T0 and T1, patients will come for 2 study days for 8 hours: On one study day, a
single meal will be served, on the second study day, three small isocaloric meals, with the
order of the conditions randomly assigned. The total amount of calories and the overall
nutrient composition will be equivalent between conditions. The meals will be either all
solid or all liquid. Patients enrolled in the study will be randomly assigned to solid or
liquid test meals.
Gastric emptying will be measured by the acetaminophen test.
incretin levels after GBP. Patients will be studied before GBP (T0) and 12-15 months after
GBP (T1). At T0 and T1, patients will come for 2 study days for 8 hours: On one study day, a
single meal will be served, on the second study day, three small isocaloric meals, with the
order of the conditions randomly assigned. The total amount of calories and the overall
nutrient composition will be equivalent between conditions. The meals will be either all
solid or all liquid. Patients enrolled in the study will be randomly assigned to solid or
liquid test meals.
Gastric emptying will be measured by the acetaminophen test.
Inclusion Criteria:
- Severely obese patients undergoing gastric bypass surgery (GBP)
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