Magnetic Resonance Imaging (MRI) in Motion
| Status: | Completed |
|---|---|
| Conditions: | Lung Cancer, Liver Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 5/6/2017 |
| Start Date: | November 2011 |
| End Date: | August 2015 |
Magnetic Resonance Imaging ( MRI) for Radiation Therapy Treatment Planning Evaluation of Lung, Liver and Pancreatic Motion.
This study is a research initiative established to explore the use of magnetic resonance
imaging (MRI) as a tool for detecting organ motion as it pertains to planning radiation
therapy.
imaging (MRI) as a tool for detecting organ motion as it pertains to planning radiation
therapy.
The goal with radiation therapy is to treat the defined tumor and spare the surrounding
normal tissue from receiving dose above specified tolerance doses. There is evidence of
improved local control and survival with higher doses of radiation, however, at the same
time there is the need to spare normal tissues from higher doses of radiation. Technologies
that allow the delivery of an increased radiation dose to the tumor while sparing normal
tissue have the potential of improving the therapeutic ratio. However, the development of
these technologies has been hampered by organ respiratory motion particularly in the case of
the lungs and liver. Inadequate radiation coverage of a tumor secondary to organ motion can
lead to delivering a lower dose to a portion of the tumor. Making the field of radiation
larger to account for organ motion results in unnecessary radiation dose to surrounding
healthy tissues. It is therefore desirable to document the extent of motion of the organ in
question prior to carrying out the radiation treatment planning. The organ motion impacts
directly on the radiation dose distribution in the treatment volume.
normal tissue from receiving dose above specified tolerance doses. There is evidence of
improved local control and survival with higher doses of radiation, however, at the same
time there is the need to spare normal tissues from higher doses of radiation. Technologies
that allow the delivery of an increased radiation dose to the tumor while sparing normal
tissue have the potential of improving the therapeutic ratio. However, the development of
these technologies has been hampered by organ respiratory motion particularly in the case of
the lungs and liver. Inadequate radiation coverage of a tumor secondary to organ motion can
lead to delivering a lower dose to a portion of the tumor. Making the field of radiation
larger to account for organ motion results in unnecessary radiation dose to surrounding
healthy tissues. It is therefore desirable to document the extent of motion of the organ in
question prior to carrying out the radiation treatment planning. The organ motion impacts
directly on the radiation dose distribution in the treatment volume.
Inclusion Criteria:
- Age ≥ 21
- Patients with primary or metastatic tumors in the lungs, liver, or pancreas
- Patients undergoing a planning CT scan in the Department of Radiation Oncology with
tumor motion assessment - planning 4D-CT ordered by the treating Radiation Oncologist
- Signed, specific informed consent prior to study entry
Exclusion Criteria:
- Any condition for which a MRI procedure is contraindicated including presence of
metallic material in the body, such as pacemakers, non- MRI compatible surgical
clips, shrapnel, etc
- Pregnant or breast-feeding women
- Subjects who have difficulty lying flat on their back for extended periods of time
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