Prevention of Infection in Closed Fractures: Cefazolin Versus Vancomycin



Status:Terminated
Conditions:Infectious Disease, Orthopedic
Therapuetic Areas:Immunology / Infectious Diseases, Orthopedics / Podiatry
Healthy:No
Age Range:18 - 85
Updated:7/13/2018
Start Date:October 2009
End Date:December 2017

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Trial Summary
Trial Overview
Inclusion Criteria

Prevention of Infection in Surgical Treatment of Closed Fractures: A Comparative Study of Cefazolin Versus Vancomycin

The purpose of this study is to compare the incidence rate of infection in surgical patients
with closed fractures treated prophylactically with Cefazolin versus Vancomycin in the
peri-operative period.

The hypothesis of this study is that patients undergoing surgical treatment for closed
fractures who are treated prophylactically with Vancomycin will have a lower incidence rate
of infection than patients who are treated prophylactically with Cefazolin.


Inclusion Criteria:

- Between 18 years old and 85 years old

- Closed fracture

- Fracture treatment plan is for one operation on one day (one surgical setting)

- Likely to follow-up with surgeon until fracture is healed

- Ability to understand and agree to Informed Consent

Exclusion Criteria:

- Under 18 years old or over 85 years old

- Open fracture(s)

- Fracture requires multiple operations

- Other injuries requiring operations

- Documented allergy to Cefazolin or Vancomycin

- Previous history of Methicillin-resistant Staphylococcus aureus infection

- Previous surgery on the injured extremity within 1 year

- Use of antibiotics within 2 weeks before or after injury

- Use of antibiotics within 2 weeks before surgery

- Unlikely to follow-up until fracture is healed

- Unable to understand and agree to Informed Consent
We found this trial at
1
site
Erlanger Health System
Chattanooga, Tennessee 37403
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mi
from
Chattanooga, TN
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