Utilization of Leukocyte Esterase in the Diagnosis of Pediatric Joint Infections
| Status: | Terminated |
|---|---|
| Conditions: | Arthritis, Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases, Rheumatology |
| Healthy: | No |
| Age Range: | Any - 18 |
| Updated: | 12/1/2018 |
| Start Date: | December 2013 |
| End Date: | December 2016 |
Pediatric joint infections are a common diagnostic dilemma encountered by treating
orthopaedic surgeons. No single test is sensitive or specific enough to stand alone in
determining the presence of joint infection.
The purpose of this study is to test the usefulness of a chemical test strip to detect
infection in fluid that is removed from a joint (intra-articular aspiration) in pediatric
patients. The test strip measures an enzyme called leukocyte esterase, which has been shown
to be useful in detecting the presence of infection in fluids from other parts of the body.
This study will assess the efficacy of the leukocyte esterase test as a diagnostic tool for
evaluating pediatric joint infections. The hypothesis of the study is that a positive
leukocyte esterase test identifies a septic joint in pediatric patients undergoing
intraoperative joint aspiration.
orthopaedic surgeons. No single test is sensitive or specific enough to stand alone in
determining the presence of joint infection.
The purpose of this study is to test the usefulness of a chemical test strip to detect
infection in fluid that is removed from a joint (intra-articular aspiration) in pediatric
patients. The test strip measures an enzyme called leukocyte esterase, which has been shown
to be useful in detecting the presence of infection in fluids from other parts of the body.
This study will assess the efficacy of the leukocyte esterase test as a diagnostic tool for
evaluating pediatric joint infections. The hypothesis of the study is that a positive
leukocyte esterase test identifies a septic joint in pediatric patients undergoing
intraoperative joint aspiration.
Pediatric patients requiring an intra-articular joint aspiration for suspected infection or
for other reasons will have a leukocyte esterase test performed on fluid removed from the
joint. A convenience sample of consecutive patients will be screened according to
inclusion/exclusion criteria and enrolled in the study by informed consent. All patients who
will be screened for the study will have already been identified as needing an
intra-articular joint aspiration in accordance with standard of care. All patients who are
enrolled in the study will have the leukocyte esterase test performed on the fluid that is
aspirated. Results of the test strip will be recorded.
for other reasons will have a leukocyte esterase test performed on fluid removed from the
joint. A convenience sample of consecutive patients will be screened according to
inclusion/exclusion criteria and enrolled in the study by informed consent. All patients who
will be screened for the study will have already been identified as needing an
intra-articular joint aspiration in accordance with standard of care. All patients who are
enrolled in the study will have the leukocyte esterase test performed on the fluid that is
aspirated. Results of the test strip will be recorded.
Inclusion Criteria:
- All patients at this facility over the age of 3 months and below the age of 18 years
who receive an intra-articular aspiration
Exclusion Criteria:
- Immunocompromised patients
- Renal failure patients
- Patients younger than 3 months old
- Patients 18 years of age or older
- Volume of aspirate is less than 1.5 mL
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