Supplementation With Omega-3: Mechanism of Action
| Status: | Terminated |
|---|---|
| Conditions: | High Cholesterol, Metabolic |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Pharmacology / Toxicology |
| Healthy: | No |
| Age Range: | 20 - 75 |
| Updated: | 3/2/2017 |
| Start Date: | April 2013 |
| End Date: | January 2015 |
This is a trial of two marketed fish oil supplements, one with a high EPA:DHA ratio and the
other with a high DHA:EPA ratio, to examine differential effects on platelet function, blood
pressure, and fasting triglyceride levels.
other with a high DHA:EPA ratio, to examine differential effects on platelet function, blood
pressure, and fasting triglyceride levels.
Observational studies have shown that fish consumption is associated with a lower risk of
cardiovascular disease, and clinical trials have demonstrated that fish oil nutritional
supplementation is associated with improvement in cardiometabolic risk factor profiles
including fasting triglycerides and blood pressure. However, the mechanisms of action of
fish oils are not well understood. Specifically, the effects of different compositions in
terms of the ratio of the fatty acids EPA and DHA are not known. We are proposing a pilot
and feasibility study of fish oil nutritional supplementation in 40 healthy adult
participants with two different commercially available fish oil (high EPA/DHA ratio, high
DHA/EPA ratio, sample of 20 per group) with the hypothesis that 4 weeks of supplementation
with fish oil results in differential changes in platelet function, blood pressure and
fasting triglyceride levels . We will also bank blood and urine for future mechanistic
studies. This pilot study will allow us to collect preliminary data for definitive
mechanistic studies of the effects of fish oil supplementation and to demonstrate the
feasibility of this protocol.
cardiovascular disease, and clinical trials have demonstrated that fish oil nutritional
supplementation is associated with improvement in cardiometabolic risk factor profiles
including fasting triglycerides and blood pressure. However, the mechanisms of action of
fish oils are not well understood. Specifically, the effects of different compositions in
terms of the ratio of the fatty acids EPA and DHA are not known. We are proposing a pilot
and feasibility study of fish oil nutritional supplementation in 40 healthy adult
participants with two different commercially available fish oil (high EPA/DHA ratio, high
DHA/EPA ratio, sample of 20 per group) with the hypothesis that 4 weeks of supplementation
with fish oil results in differential changes in platelet function, blood pressure and
fasting triglyceride levels . We will also bank blood and urine for future mechanistic
studies. This pilot study will allow us to collect preliminary data for definitive
mechanistic studies of the effects of fish oil supplementation and to demonstrate the
feasibility of this protocol.
Inclusion Criteria:
- Healthy adults 20-75 years of age.
- Participant of the Principal Investigator's prior studies studies who have agreed to
be contacted for future studies.
Exclusion Criteria:
- Current user of fish oil supplements
- Current user of statins
- Allergy to fish or seafood products
- Diagnosed/treated diabetes mellitus
- Using aspirin or NSAIDS or other "blood-thinning medication"
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Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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