Tranexamic Acid in Orthopaedic Trauma Surgery
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Hospital, Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/13/2018 |
| Start Date: | May 2012 |
| End Date: | December 2018 |
Tranexamic acid is an antifibrinolytic drug that has been used to decrease post-operative
blood loss. This study is a prospective, randomized controlled trial investigating the use of
tranexamic acid in fracture surgery around the hip and knee, in which significant blood loss
(>300mL) is expected.
The hypothesis of this study is that tranexamic acid will be associated with a decrease in
post-operative blood loss, as well as a decreased need for allogenic blood transfusion, in
patients who have fracture surgery around the hip and knee.
blood loss. This study is a prospective, randomized controlled trial investigating the use of
tranexamic acid in fracture surgery around the hip and knee, in which significant blood loss
(>300mL) is expected.
The hypothesis of this study is that tranexamic acid will be associated with a decrease in
post-operative blood loss, as well as a decreased need for allogenic blood transfusion, in
patients who have fracture surgery around the hip and knee.
Inclusion Criteria:
- Patients with isolated fractures of the pelvic ring, acetabulum, femur or tibia that
will require open reduction and internal fixation
- Expected blood loss is greater than 300 mL
- Age ≥ 18
- Skeletal maturity
Exclusion Criteria:
- Pregnant or breastfeeding
- Patients taking oral contraceptives
- Contraindication to venous thromboembolic event (VTE) prophylaxis (intracranial,
intrathoracic, intra-abdominal bleeding or spine fractures)
- Patients requiring operative intervention for other injuries (orthopaedic or
non-orthopaedic)
- Known hypercoagulable state including history of prescribed anti-coagulation
(warfarin, plavix, low molecular weight heparin)
- Renal Insufficiency (creatinine greater than 1.5mg/dL)
- Open fractures
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