Exercise, Heart Failure, and Type 2 Diabetes
Status: | Withdrawn |
---|---|
Conditions: | Cardiology, Diabetes |
Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology |
Healthy: | No |
Age Range: | 50 - Any |
Updated: | 4/21/2016 |
Start Date: | February 2012 |
Vascular and Metabolic Responses to Exercise Training in Heart Failure With or Without Type 2 Diabetes
The purpose of this study is to understand the differences in how patients with heart
failure respond to exercise training compared to patients with heart failure and type 2
diabetes.
failure respond to exercise training compared to patients with heart failure and type 2
diabetes.
The investigators will measure exercise capacity in patients with heart failure or heart
failure plus type 2 diabetes prior to and following a 12-week exercise training program
(5d/wk, 30 min/d, 60-75% VO2max) to determine whether improvements in exercise capacity in
response to exercise training are mitigated in patients with combined heart failure plus
type 2 diabetes.
failure plus type 2 diabetes prior to and following a 12-week exercise training program
(5d/wk, 30 min/d, 60-75% VO2max) to determine whether improvements in exercise capacity in
response to exercise training are mitigated in patients with combined heart failure plus
type 2 diabetes.
Inclusion Criteria:
- ≥50 yr of age
- New York Heart Association class II-III CHF and ejection fraction ≤35%
- receiving optimal medical therapy
- sedentary (≤ 30 min/wk structured physical activity).
- Half of volunteers (n=30) will have a diagnosis of type 2 diabetes (CHF+T2D).
Exclusion Criteria:
- smoking
- changes in medication ≤6 wk prior to enrollment
- major cardiovascular event or procedure ≤6 wk prior to enrollment
- foot ulcers
- advanced neuropathy
- co-morbidities or other limitations that may interfere with or prevent volunteers
from safely completing the exercise training
- fixed rate pacemaker
- type 1 diabetes mellitus
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