Exercise, Heart Failure, and Type 2 Diabetes



Status:Withdrawn
Conditions:Cardiology, Diabetes
Therapuetic Areas:Cardiology / Vascular Diseases, Endocrinology
Healthy:No
Age Range:50 - Any
Updated:4/21/2016
Start Date:February 2012

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Vascular and Metabolic Responses to Exercise Training in Heart Failure With or Without Type 2 Diabetes

The purpose of this study is to understand the differences in how patients with heart
failure respond to exercise training compared to patients with heart failure and type 2
diabetes.

The investigators will measure exercise capacity in patients with heart failure or heart
failure plus type 2 diabetes prior to and following a 12-week exercise training program
(5d/wk, 30 min/d, 60-75% VO2max) to determine whether improvements in exercise capacity in
response to exercise training are mitigated in patients with combined heart failure plus
type 2 diabetes.

Inclusion Criteria:

- ≥50 yr of age

- New York Heart Association class II-III CHF and ejection fraction ≤35%

- receiving optimal medical therapy

- sedentary (≤ 30 min/wk structured physical activity).

- Half of volunteers (n=30) will have a diagnosis of type 2 diabetes (CHF+T2D).

Exclusion Criteria:

- smoking

- changes in medication ≤6 wk prior to enrollment

- major cardiovascular event or procedure ≤6 wk prior to enrollment

- foot ulcers

- advanced neuropathy

- co-morbidities or other limitations that may interfere with or prevent volunteers
from safely completing the exercise training

- fixed rate pacemaker

- type 1 diabetes mellitus
We found this trial at
1
site
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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from
Durham, NC
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