Zinc Bioavailability From Amaranth-enriched Maize Tortillas
| Status: | Completed |
|---|---|
| Conditions: | Food Studies |
| Therapuetic Areas: | Pharmacology / Toxicology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | January 2012 |
| End Date: | December 2015 |
Absorption of Zinc (Zn) From Traditional Maize Tortillas and Amaranth-enriched Tortillas by Toddlers in the Indigenous Post-Mayan Population
Young children in Guatemala are at risk for nutrient deficiencies due to plant-based diets
and poor sanitation. Stunting, frequent diarrhea, and respiratory infections are common.
Supplementation of Zn to children during diarrhea episodes has been shown to diminish
duration and severity of illness. Poor Zn absorption due to high fiber and phytate in this
diet might play a role in these processes. Supplementation of this micronutrient in the diet
might be beneficial. The investigators will compare absorption of Zn from white maize
tortillas enriched with 20% amaranth to traditional white corn tortillas in preschool
children in Guatemala.
and poor sanitation. Stunting, frequent diarrhea, and respiratory infections are common.
Supplementation of Zn to children during diarrhea episodes has been shown to diminish
duration and severity of illness. Poor Zn absorption due to high fiber and phytate in this
diet might play a role in these processes. Supplementation of this micronutrient in the diet
might be beneficial. The investigators will compare absorption of Zn from white maize
tortillas enriched with 20% amaranth to traditional white corn tortillas in preschool
children in Guatemala.
This is a randomized cross-over study of zinc absorption in young children living in the
Western Highlands of Guatemala. Absorption of zinc will be measured from maize tortillas and
maize tortillas fortified with 20% amaranth as the major food staple which provides at least
70% energy and at least 90% zinc and phytate of the diet. Participants will be randomized as
to which type of tortilla they receive on the first and second day. Fractional absorption of
zinc (FAZ) from all meals in one day for one type of tortilla and one day for the other will
be measured by extrinsic labeling with stable isotopes of zinc. FAZ will be measured by a
dual isotope tracer ratio (DITR) technique based on ratio of urine enrichment of orally
versus intravenously administered zinc stable isotopes. Measurement of total zinc in
duplicate diets on test days allow for determination of quantities of this micronutrient
absorbed.
Western Highlands of Guatemala. Absorption of zinc will be measured from maize tortillas and
maize tortillas fortified with 20% amaranth as the major food staple which provides at least
70% energy and at least 90% zinc and phytate of the diet. Participants will be randomized as
to which type of tortilla they receive on the first and second day. Fractional absorption of
zinc (FAZ) from all meals in one day for one type of tortilla and one day for the other will
be measured by extrinsic labeling with stable isotopes of zinc. FAZ will be measured by a
dual isotope tracer ratio (DITR) technique based on ratio of urine enrichment of orally
versus intravenously administered zinc stable isotopes. Measurement of total zinc in
duplicate diets on test days allow for determination of quantities of this micronutrient
absorbed.
Inclusion Criteria:
- 2-3 years of age
- apparently healthy
- eats >2-3 tortillas at each meal of the day.
Exclusion Criteria:
- Chispitas or macrovital supplementation
- breastfeeding
- birth weight < 2,500 g
- birth defect affecting growth and development
- chronic infection
- twin or triplet
- sibling enrolled in study
We found this trial at
2
sites
Click here to add this to my saved trials
13001 E 17th Pl
Aurora, Colorado 80045
Aurora, Colorado 80045
(303) 724-5000
University of Colorado Anschutz Medical Campus Located in the Denver metro area near the Rocky...
Click here to add this to my saved trials